Lymphocyte function

Question 1

All lymphocytes are antigen specific. How is this specificity achieved?

Answer 1

Specificity is achieved by antigen receptor on cell surface

Question 2

What is the receptor for B cells and T cells?

Answer 2

B cells receptor = cell-surface antibody

T cells receptor = T cell receptor (TCR)

Question 3

What are mmunoglobulins are synthesised and secreted by?

Answer 3

B cells

Question 4

What must happen to a B cell to be able to secrete Ig?

Answer 4

1. activated by binding to antigen
2. differentiate into PLASMA cells
3. Antigen receptor on B cells is the form antibody that the B cell is programmed to make

Question 5

How is the Generation of antibody diversity achieved?

Answer 5

Antibodies being encoded by multiple gene segments.

Question 6

What type of Ig does a B cells begin by making?

How are the rest produced?

Answer 6

IgM

Memory cells produce IgA, IgG, IgE

Question 7

T cells fall into two major classes, which have different effector functions and are distinguished by the expression of the cell-surface proteins CD4 and CD8.

What are the 2 classes and what cell surface protein belongs with each?

Answer 7

On helper T cells TCR is associated with CD4 + CD3

On cytotoxic T cells TCR is associated with CD8 + CD3

Question 8

After binding antigen, T_H cells secrete what?

Answer 8

After binding antigen, T_H cells secrete growth factors (cytokines) which control immune response

Question 9

After binding with antigen, activated T_C release what?

Answer 9

•Release perforins which form pores in target cell