LYMPHATIC SYSTEM Flashcards
Lymphatics develop by
6-7 weeks of GESTATION
⭐ LOWER LIMB & ABDOMINAL LYMPHATICS drain into
⭐ Upper LIMB & Head & Neck LYMPHATICS drain into
⭐ LOWER LIMB & ABDOMINAL LYMPHATICS drain into
🎯 THORACIC DUCT (via CISTERNA Chylii)
⭐ Upper LIMB & Head & Neck LYMPHATICS drain into
🎯 Right INTERNAL jugular Vein
LYMPHATIC SYSTEM starts DEVELOPING by
6-7 weeks of GESTATION
Which LYMPHATIC vessels have VALVES?
Terminal LYMPHATICS (have BICUSPID Valve)
How LYMPHATIC Vessels push their content forward?
- Lymphangions are CONTRACTILE in Nature
⬇️
Pushes the LYMPH FORWARD - Transient ⬆️ in INTERSTITIAL pressure 2° to MUSCLE CONTRACTION
- Prevention of REFLUX by VALVES
Lymphangions
Valves partition LYMPHATICS into segments
CYSTIC HYGROMA develops DUE TO:
Sequestered LYMPHATIC tissue
⬇️
Cyst does NOT Communicate with NORMAL Lymphatics
⬇️
Lymph gets absorbed, Clear Fluid ➕
⚡⚡ MOST COMMON SITE OF CYSTIC HYGROMA
POSTERIOR triangle of NECK
Other:
Axilla
Inguinal Region
🧑🏻⚕️ Clinical Features of CYSTIC HYGROMA
- Fluctuations ➕
- Partly COMPRESSIBLE
- Brilliantly TRANS-ILLUMINANT swelling
Brilliantly TRANS-ILLUMINANT swelling
🧠⚡CREaM H ⚡
• Hydrocele
• Epididymal cyst
• Cystic hygroma
• Ranula
• Meningocele
Presentation of CYSTIC HYGROMA
- Detected in-utero in USG
- Obstructed labor
- RESPIRATORY distress
- Swelling
- Secondary Infection
🩺 IOC for CYSTIC HYGROMA
FNAC
💊💉 MANAGEMENT of CYSTIC HYGROMA
⭐ Normal Lesion
⭐ Very Large Lesion
⭐ Normal Lesion
Aspiration ➡️ Surgery
⭐ Very Large Lesion
Aspiration ➕ Sclerotherapy
⬇️
Surgery
Which nerve can get injured during CYSTIC HYGROMA Surgery
Spinal Accessory Nerve
⬇️
Shoulder Dysfunctions
Organisms ASSOCIATED with ACUTE LYMPHANGITIS
- Streptococcus
- Staphylococcus aureus
🧑🏻⚕️ Clinical Features of ACUTE LYMPHANGITIS
- Pain
- Reddish Streaks
- Fever
💊💉 MANAGEMENT of ACUTE LYMPHANGITIS
- Limb elevation
- Analgesics
- Broad spectrum antibiotics
- If ≥ 48 hours ➡️ Suspect ABSCESS
⬇️
INCISION & DRAINAGE
Lymphedema
meaning
Occurs DUE TO: Inability of LYMPHATIC System to clear INTERSTITIAL FLUID COMPARTMENT
⭐ 1° LYMPHEDEMA
⭐ 2° LYMPHEDEMA
⭐ 1° LYMPHEDEMA
🎯 PRODUCTION is NORMAL ➕ DEFECTIVE LYMPHATICS
⭐ 2° LYMPHEDEMA
🎯 ⬆️ PRODUCTION (OR) ⬇️ DRAINAGE
Effect of LYMPH STASIS
⭐ Fibrosis
⭐ Skin Changes
🧑🏻⚕️ Clinical Features of LYMPHEDEMA
✨ Lymph swelling
✨ Dull aching (OR) Sharp PAIN
✨ Skin changes
Brunner’s classification used for
Clinical classification of LYMPHEDEMA
Brunner’s CLASSIFICATION
Skin changes in LYMPHEDEMA
- BUFFALO HUMP: Loss of ANKLE CONTOUR
- STEMMER’S SIGN: Skin becomes FIBROSED & CANNOT BE PINCHED
- Squaring of TOES
- Fungal Infections
- Cancer development
Identify
STEMMER’S SIGN
Identify
Buffalo HUMP sign
Identify
SQUARING OF TOES
Gold standard for QUANTIFICATION OF LYMPHEDEMA
Water Plethysmography
GOLD STANDARD TO IDENTIFY TYPE OF LYMPHEDEMA
⭐ DYE USED
Direct LYMPHANGIOGRAPHY
⭐ INDIGO CYANIN GREEN
Patterns of 1° LYMPHEDEMA
- Congenital Hyperplasia of LYMPHATICS
- DISTAL OBSTRUCTION
- PROXIMAL OBSTRUCTION
Congenital Hyperplasia of LYMPHATICS
⬆️ in NUMBER of LYMPHATICS but they are DEFECTIVE
⚡⚡ MOST COMMON PRIMARY LYMPHEDEMA
LYMPHEDEMA PRAECOX
⚡⚡ MOST COMMON PATTERN seen in LYMPHEDEMA PRAECOX
Distal OBSTRUCTION
Proximal OBLITERATION
OBSTRUCTION at level of AORTO-ILIAC & INGUINAL NODES
Which INVESTIGATION is useful to DIFFERENTIATE LYMPHEDEMA, VENOUS EDEMA & LIPOEDEMA
Single AXIAL CT through MID-CALF
Single AXIAL CT through MID-CALF findings
LYMPHEDEMA
🎯 RETICULAR, HONEYCOMB pattern in an enlarged SUBCUTANEOUS compartn5
VENOUS EDEMA
🎯 ⬆️ Volume of MUSCULAR COMPARTMENT
LIPOEDEMA
🎯 ⬆️ SUBCUTANEOUS FAT
LIPOEDEMA: 🧑🏻⚕️ Clinical Features
- Symmetrical
- B/L
- ♀️ > ♂️
1° LYMPHEDEMA
🧠⚡CPT⚡
- Lymphedema Congenita
- Lymphedema PRAECOX
- Lymphedema TARDA
⚡⚡ MOST COMMON AGE GROUP FOR
- Lymphedema Congenita
- Lymphedema PRAECOX
- Lymphedema TARDA
- Lymphedema Congenita
🎯 0-2 years - Lymphedema PRAECOX
🎯 2-35 yrs - Lymphedema TARDA
🎯 > 35 yrs
GENDER PREDOMINANT IN
- Lymphedema Congenita
- Lymphedema PRAECOX
- Lymphedema TARDA
- Lymphedema Congenita
🎯 ♂️ > ♀️ - Lymphedema PRAECOX
🎯 ♀️> ♂️ - Lymphedema TARDA
🎯 ♂️ > ♀️
Familial VARIENT OF
1. Lymphedema Congenita
2. Lymphedema PRAECOX
- Lymphedema Congenita
🎯 NOONE MILROY SYNDROME - Lymphedema PRAECOX
🎯 MEIGE’S DISEASE
Body parts involved in:
- Lymphedema Congenita
- Lymphedema PRAECOX
- Lymphedema Congenita
🎯 Multiple Limbs, Face & Genitalia - Lymphedema PRAECOX
🎯 U/L Lower Limb till Knee
Noone MILROY SYNDROME
⭐ MUTATION
Familial LYMPHEDEMA Congenita
⭐ FLT-4
⭐ VEGF
MEIGE’S DISEASE
⭐ MUTATIONS
Familial LYMPHEDEMA PRAECOX
⭐ GJC gene
SYNDROMES ASSOCIATED with LYMPHEDEMA
- HENNEKAM SYNDROME
- EMBERGER SYNDROME
- OLEDAID SYNDROME
Microcephaly
➕
Unusual Facies
➕
LYMPHEDEMA affecting all 4 limbs
HENNEKAM SYNDROME
HENNEKAM SYNDROME
MUTATION
FAT4 gene
Myelodysplasia
➕
Warts
➕
RECURRENT Viral & Bacterial Infections
➕
Hypoplasia of LYMPHATICS
Emberger SYNDROME
EMBERGER SYNDROME
Mutation
GATA2
Ectodermal dysplasia
➕
Anhidrotic
➕
Osteopetrosis
➕
Immunodeficiency
OLEDAID Syndrome
OLEDAID Syndrome
MUTATION
IKBKG gene
⚡⚡ MOST COMMON CAUSE of LYMPHEDEMA OVERALL
Filariasis
⚡⚡ MOST COMMON CAUSE of LYMPHEDEMA in UPPER LIMB
⚡⚡ MOST COMMON CAUSE of LYMPHEDEMA in LOWER LIMB
⚡⚡ MOST COMMON CAUSE of LYMPHEDEMA in UPPER LIMB
🎯 POST-MASTECTOMY LYMPHEDEMA
⚡⚡ MOST COMMON CAUSE of LYMPHEDEMA in LOWER LIMB
🎯 FILARIASIS
CHANCE OF POST-MASTECTOMY LYMPHEDEMA is ⬆️ ⬆️ if
- Radiotherapy is given to AXILLA after Surgery
- Lymph node Clearance above AXILLARY VEIN
Effect of DEC in ELEPHANTIASIS Treatment
⭐ Kills Microfilariae
⭐ Cannot REVERSE LYMPHEDEMA (OR) Skin Changes
STEWART TREVE’S SYNDROME
Development of LYMPHANGIOSARCOMA in long standing LYMPHEDEMA (8-10yrs)
💊💉 MANAGEMENT of STEWART TREVE’S SYNDROME
Aggressive SURGERY & CHEMOTHERAPY
STEWART
Cancers ASSOCIATED with LYMPHEDEMA
- Lymphangiosarcoma
- Kaposi Sarcoma
- Squamous cell Carcinoma
- Liposarcoma
- Basal cell Carcinoma
- MALIGNANT melanoma
- Lymphoma
Lymphangioma
Dilated LYMPHATIC can THROMBOSE in LONG RUN
⬇️
FIBROSIS
⬇️
Form NODULES
🌸 TYPES of LYMPHANGIOMA
🧠⚡ACD ⚡
- LYMPHANGIOMA AB IGNE: Arranged in RETICULAR FASHION
- LYMPHANGIOMA CIRCUMSCRIPTUM:
< 5 cm - LYMPHANGIOMA DIFFUSUM: > 5cm
💊💉 MANAGEMENT of LYMPHEDEMA
- Pain Relief
- Skin Care
- Control of SWELLING: Decongestive LYMPHEDEMA Therapy
✨ 1st Phase: INTENSIVE SUPERVISED THERAPY
✨ 2nd Phase: MAINTAINANCE Phase: Self Care Regime - Exercise: Slow rhythmic movements & Swimming
- Surgery
✨ Reconstructive
✨ Resective
1st Phase: INTENSIVE SUPERVISED THERAPY includes
- Manual LYMPHATIC drainage
- Multiplayer LYMPHEDEMA bandaging
MLLB
Advantages
Difference BETWEEN Compression Stockings for VARICOSE VEINS & PRESSURE GARMENTS
If ARTERIAL DISEASE is ➕, with LYMPHEDEMA, MLLB can be only DONE if
ABPI > 0.8-0.9
Vigorous Exercise & Anaerobic Isometric Exercise can
WORSEN LYMPHEDEMA
Indications of SURGICAL MANAGEMENT in LYMPHEDEMA
- ⬆️ in SWELLING DESPITE MEDICAL Management
- Skin Changes
- RECURRENT Infections
Types of SURGICAL PROCEDURES in LYMPHEDEMA
⭐ Reconstructive
✨ KINMOTH Procedure
✨ NEBULOWITZ Procedure
⭐ RESECTIVE
✨ Homan’s procedure
✨ Thompson procedure
✨ Sistrunk Procedure
✨ Charles Procedure
KINMOTH Procedure
Ileal Mucosal Patch anastamosis
NEBULOWITZ PROCEDURE
⭐ Super Microsurgery
Anastamosis of LYMPH NODES & LYMPHATICS with VEINS
Homan’s Procedure
Wedge of Skin & SUBCUTANEOUS tissue is removed
⚡⚡ MOST COMMON COMPLICATION OF Homan’s Procedure
Skin NECROSIS
⚡⚡ MOST SATISFYING SURGERY FOR CALF LYMPHEDEMA
Homan’s Procedure
THOMPSON PROCEDURE
Flap is RAISED & SUBCUTANEOUS tissue is cleared
⬇️
Flap is de-epithelized & sutured
⚡⚡ MOST COMMON COMPLICATION OF THOMPSON PROCEDURE
Skin Necrosis
⚡⚡ MOST COMMONLY DONE RESECTIVE SURGERY PROCEDURE
SISTRUNK PROCEDURE
SISTRUNK PROCEDURE
Wedge of skin & SUBCUTANEOUS tissue is resected & Primary Closure is done
⚡⚡ MOST DISFIGURATIVE PROCEDURE FOR LYMPHEDEMA MANAGEMENT
Charles Procedure
CHARLES PROCEDURE
Entire skin is removed
⬇️
Split Thickness Skin Grafting
Pilonidal Sinus Formation is COMMONLY seen following
THOMPSON’S PROCEDURE
Hydrocele of the Neck
Cystic Hygroma
Cyst in Cystic Hygroma is
Multilocular