Lymph system quiz Flashcards
Non Specific Resistance (innate defense) 1st line
Skin, Mucous membranes, Mucus, Hairs, cilia, Lacrimal apparatus, saliva, urine, defecation and vomiting
Sebum, lysozyme, gastric juice, vaginal secrations
Chemicals increase Vasodilation and increased permeability
Histamine (by must cells, basophils and platelets, stimulated by Neutrophils and Macrophages)
Kinins (bradykinin, chemotactic agents for phagocytes)
Prostaglandins (by damaged cells, intensify the effect of histamine and kinds, emigration of phagocyte)
Leukotriens (LTs, produced by basophils and must cell, adherence of phagocytes to pathogens)
Complement
Non Specific resistance (Innate defense) 2nd line
Antimicrobial Proteins (interferons, complement system, transferrins), Natural killer (NK) cells Phagocytes (Neutrophils and Macrophages) Inflammation Fever
Interferon released by
virus infected cells to interfere with viral replication (antimicrobial substances)
Complement made up of
Antimicrobial substance: normally inactive proteins in blood plasma and on plasma membranes
Cytolysis of microbes, phagocytosis (opsonization), contribution to inflammation
Iron-binding proteins
Antimicrobial substances
Transferrin, lactoferrin, ferrietin, hemoglobin
Antimicrobial proteins
Antimicrobial substances: Dermicidin, defensins, catherlicidins, thrombocidin
immunoglobulins is
antibody, glycoproteingroup contain 4 polypeptide chains
Hapten is an antigen
Reactivity but not immunogenicity
Monocytes differentiate to
Wandering macrophage
Natural killer cells are
lymphocytes
lymphatic vessel is most similar to that of a
vein
interleukin 1
by macrophage, proliferation of helper T Cells, acts on phypohtalamus to cause ever
interleukin 2
by helper T cells, costimulates proliferation of helper T cell,
Interleukin 4
by helper T cells, costimulator for B cells, causes plasma cell to secrete IgE antibodies,
Interleukin 5
by helper T cells, costimulator for B cells, causes plasma cells to secrete IgA antibodies
Interleukin 6
Produced by helpter T cells, B cell differentiation into plasma cells
Tumor necrosis factor
by macrophages, stimulates accumulation of neutrophils and macrophages at the sites of inflammation and stimulates their killing of microves
Macrophage migration inhibiting factor
produced by cytotoxic T cells, prevents macrophages from leaving site of infection
activation of T cells
First signal T cell receptors recognize and bid to specific foreign antigen fragments that are presented in antigen -MHC complexes.
Second signal if it binds to foreign antigen and at the same time receives costimulation such as interleukin 2
Antigen presenting cells
Dendritic cells, macrophages, B cells
Cytotoxic T Cells activated by
Interleukin 2 or other cytokines activated by other active T helper cells
Cytotoxic T cells kills
infected target cells, cancer cells, and transplanted cells
Cytotoxic T cells releases
Perforin or granulysin to pierces the cell
Granzyme - protein digesting enzymes that trigger apoptosis, with microbes killed by phagocytes
Lymphotoxin - activated enzyme in the target cell - DNA fragments