lymph + onocology Flashcards

1
Q

Functions of lymphatic system

A

drain excess interstitial fluid
absorption and transportation of dietary lipids
produce lymphocytes - immune response
filter pathogens

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2
Q

2 ducts lymph is drained by

A

right lymphatic duct
thoracic duct

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3
Q

where does right lymphatic duct drain lymph from

A

right side of head and neck
right arm
right side of thorax

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4
Q

what is right thoracic duct formed by

A

right subclavian trunk (upper limb)
right bronchomediastinal trunk (thoracic wall, lung and heart)
right jugular trunk (head and neck)

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5
Q

where does the thoracic duct drain lymph from

A

from rest of body
LHS of thorax and lower extremities

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6
Q

what is thoracic duct formed by

A

lymphatic trunks

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7
Q

where does thoracic duct commence

A

T12 above cisterna chyli

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8
Q

location of thoracic duct

A

runs upwards on RHS of descending aorta
posterior to oesophagus

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9
Q

how long is thoracic duct

A

38-45cms

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10
Q

where does thoracic duct end

A

in right atrium

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11
Q

Cisterna chill length

A

5-7cms

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12
Q

cisterna chyli location

A

inferior to thoracic duct
anterior surface of L2

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13
Q

cisterna chyli function

A

drain lymph from abdomen / pelvis / lower limbs

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14
Q

flow of lymph
highest to lowest pressure

A

blood capillaries
interstitial fluid
lymph capillaries
lymph veins and lymph nodes
lymph ducts
junction of jugular and subclavian veins

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15
Q

2 pumps that aid flow of lymph

A

skeletal muscle pump
respiratory pump

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16
Q

skeletal muscle pump - defn

A

milking action
contractions compress lymphatic vessel forcing lymph toward junction of jugular and subclavian veins

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17
Q

respiratory pump - function

A

pressure changes during inhalation
lymph flows from high to low pressure - abdomen to chest
exhalation - reverse (valve = unidirectional flow)

18
Q

nodes
head and neck

A

cervical
jugular

19
Q

nodes
axillary

A

axilla
breast
armpit
subclavian trunk

20
Q

nodes
tracheo-bronchial

A

trachea
bronchus
heart
lung
thoracic wall

21
Q

location of lymphoid organs and tissues

A

spleen
thymus
tonsils
Peyer’s patches
appendix

22
Q

lymphatic spread - defn

A

tumour cells invade local lymphatic vessels and break off to spread throughout the body to regional lymph nodes

23
Q

haematogenous spread - defn

A

tumour cells invade capillary bed and break off
carried in blood stream and develop as a secondary tumour in other organ

24
Q

trans coelomic spread - defn

A

tumour cells involving serous membrane become detached and implant in other areas of membrane

25
Q

mechanical transplantation spread - defn

A

tumour cells dislodge during biopsy or surgery and implant along track of surgical site

26
Q

thymic sail Sign - describe

A

triangular shape from inferior margin of thymus
commonly seen on RHS (can be bilateral)

27
Q

thyme sail sign can be mistaken for what pathology?

A

spinnaker sail sign - pneumomediastinum

28
Q

spinnaker sail sign - pneumomediastinum

A

gas/air trapped in pericardial sac in mediastinum

29
Q

spinnaker sail sign shape

A

large wedge shaped opacity
angel wing shape
from right hemidiaphragm to superior mediastinum

30
Q

oncology defn

A

study of neoplasms

31
Q

benign features

A

slow and progressive growth
does not invade other tissues
contained in fibrous capsule
cells closely resemble tissue of origin
mobile when palpable

32
Q

malignant features

A

rapid and progressive growth
invades local tissue
irregular shaped
fixed when palpable
detrimental effect on body

33
Q

4 steps of tumour staging

A

determine extent of tumour and metastatic spread
plan most effective treatment plan
predict risk of recurrance
predict prognosis

34
Q

TNM classification

A

T- Primary Tumour
N- Regional Lymph Nodes
M- Distant Metastasis

35
Q

T1/2/3/4

A

refers to size or extent of primary tumour

36
Q

T0

A

no evidence of invasion

37
Q

N1/2/3

A

degree of lymph node involvement

38
Q

N0

A

no lymph node involved

39
Q

M1/ M0

A

distant metastasis present yes/no

40
Q

role of diagnostic imaging

A

initial diagnosis
work-up and staging
monitoring and ?response to treatment
?follow -up recurrence