Lymph nodes, spleen, thymus

Question 1

Where is the site of B cell localization and proliferation in the LN?

Answer 1

Follicle

Question 2

Where are B cells generally found in the spleen?

Answer 2

Follicles

Question 3

Which part of the spleen houses APCs and specialized B cells?

Answer 3

Marginal zone

Question 4

Where are T cells found in the spleen?

Answer 4

PALS (periarterial lymphatic sheath)

Question 5

What type of T cells are in the thymic cortex?

Answer 5

Immature T cell

Question 6

What type of T cells are found in the thymic medulla?

Answer 6

Mature T cells

Question 7

Where are Hassall corpuscles found in the thymus, and what cells do they contain?

Answer 7

Medulla; epithelial reticular cells

Question 8

Where are T cells found in the LN?

Answer 8

Paracortex

Question 9

3 main fxns of the lymph node?

Answer 9

Nonspecific filtration by macrophages
Storage of B and T cells
Immune response activation

Question 10

Generally, there are follicles located in the LN?

Answer 10

Outer cortex

Question 11

Which type of LN follicle has pale germinal centers? Is is active or dormant?

Answer 11

Secondary follicle

Active

Question 12

Which type of LN follicle is dense? Is is active or dormant?

Answer 12

Primary follicle

Dormant

Question 13

What are the 2 main components of the LN medulla?

Answer 13

Medullary cords and medullary sinuses

Question 14

Where are macrophages mainly found in LNs?

Answer 14

Medullary sinuses

Question 15

Where are plasma cells and lymphocytes mainly found in LNs?

Answer 15

Medullary cords

Question 16

Where are reticular cells mainly found in LNs?

Answer 16

Medullary sinuses

Question 17

Which type of lymphatics of medullary sinuses communicate with?

Answer 17

Efferent

Question 18

Where is the LN paracortex found?

Answer 18

Region of cortex btwn follicles and medulla

Question 19

Where in the LN contains closely packed lymphocytes and plasma cells?

Answer 19

Medullary cords

Question 20

Where in the LN contains reticular cells and macrophages?

Answer 20

Medullary sinuses

Question 21

Which part of the LN contains HEVs, and what type of cells enter through these?

Answer 21

Paracortex; B and T cells

Question 22

What are the long, vascular channels in splenic red pulp?

Answer 22

Sinusoids

Question 23

What type of basement membrane do splenic sinusoids contain?

Answer 23

Fenestrated

Question 24

Which type of splenic pulp contains PALS?

Answer 24

White

Question 25

Which type of splenic pulp contains follicles?

Answer 25

White

Question 26

Where is the splenic marginal zone found?

Answer 26

Btwn red and white pulp

Question 27

Where in the spleen do APCs present blood-borne antigens?

Answer 27

Marginal zone

Question 28

What’s the embryologic origin of the thymus?

Answer 28

Epithelium of the 3rd pharyngeal pouch

Question 29

What’s the embryologic origin of lymphocytes?

Answer 29

Mesenchymal

Question 30

Which part of the thymus is dense, and which is pale?

Answer 30

Cortex is dense

Medulla is pale

Question 31

What type of LN hyperplasia would you see in RA?

Answer 31

Follicular (B cell region)

Question 32

What type of LN hyperplasia would you see in viral infections?

Answer 32

Paracortex hyperplasia (T cell region)

Question 33

What type of LN hyperplasia would you see in early HIV infections?

Answer 33

Follicular (B cell region)

Question 34

LAD w/ hyperplasia of sinus histiocytes tells you that those LNs are currently doing what?

Answer 34

Draining a tissue of cancer

Question 35

Which part of the LN is under-developed in DiGeorge syndrome?

Answer 35

Paracortex