Lymph nodes, spleen, thymus Flashcards
Where is the site of B cell localization and proliferation in the LN?
Follicle
Where are B cells generally found in the spleen?
Follicles
Which part of the spleen houses APCs and specialized B cells?
Marginal zone
Where are T cells found in the spleen?
PALS (periarterial lymphatic sheath)
What type of T cells are in the thymic cortex?
Immature T cell
What type of T cells are found in the thymic medulla?
Mature T cells
Where are Hassall corpuscles found in the thymus, and what cells do they contain?
Medulla; epithelial reticular cells
Where are T cells found in the LN?
Paracortex
3 main fxns of the lymph node?
Nonspecific filtration by macrophages
Storage of B and T cells
Immune response activation
Generally, there are follicles located in the LN?
Outer cortex
Which type of LN follicle has pale germinal centers? Is is active or dormant?
Secondary follicle
Active
Which type of LN follicle is dense? Is is active or dormant?
Primary follicle
Dormant
What are the 2 main components of the LN medulla?
Medullary cords and medullary sinuses
Where are macrophages mainly found in LNs?
Medullary sinuses
Where are plasma cells and lymphocytes mainly found in LNs?
Medullary cords
Where are reticular cells mainly found in LNs?
Medullary sinuses
Which type of lymphatics of medullary sinuses communicate with?
Efferent
Where is the LN paracortex found?
Region of cortex btwn follicles and medulla
Where in the LN contains closely packed lymphocytes and plasma cells?
Medullary cords
Where in the LN contains reticular cells and macrophages?
Medullary sinuses
Which part of the LN contains HEVs, and what type of cells enter through these?
Paracortex; B and T cells
What are the long, vascular channels in splenic red pulp?
Sinusoids
What type of basement membrane do splenic sinusoids contain?
Fenestrated
Which type of splenic pulp contains PALS?
White
