Lymph Nodes Flashcards
Two types of lymphoid nodules
primary nodules
secondary nodules
Primary nodules contain ____ cells
inactive B cells
Secondary nodules are sites where ____ are dividing and maturing.
activated B cells
two parts of secondary nodules
Germinal center
Cap
Dividing B cells in the dark zone are called _____
centroblasts
Centroblasts undergo _____ in the dark zone.
somatic hypermutation
Centroblasts migrate into light zone & are then known as ______
centrocytes
Centrocytes interact with ________ in the light zone
follicular dendritic cells (FDCs)
FDCs are the ______ cells of lymphoid nodules
stromal
note: rather than reticular cells
FDCs bind _____ via _____ on their plasma membranes
ag-ab complexes
Fc receptors
within a node plasma cells are most abundant in ___________
medullary cords
_____ carry lymph to the nodes
afferent lymphatics
______ receives lymph from afferent lymphatics
subcapsular sinus
______ receive lymph from the subcapsular sinus
trabecular sinuses
_____ receive lymph from trabecular sinuses
medullary sinuses