Lymph Flashcards
Self antigen vs non self antigen
Self- antigens that the body recognizes as his own body cells
Non self- foreign cells that have entered the body (get destroyed)
Nk cells
immune surveillance
Attack and destroy bacteria,host cells that are infected or cancerous
-second line of defense (nonspecific)
T (lymphocytes) cells
- matures in the thymus (depend on thymus hormones)
- second line of defense (specific)
B (lymphocytes) cells
- connective tissue cells/secretes antibodies by becoming plasma cells.
- mature in bone marrow
- needs T cells in lymph to react to antigens
- second line of defense (specific)
Macrophages
- large phagocytic cells,
- develop as monocytes the came from the bloodstream
- phagocytize debris, dead cells and foreign matter (displays fragments on surface for T cells)
- antigen presenting cells
- nonspecific, second defense
Dendritic cells
- engulf foreign matter by receptor mediated endocytosis (function like macrophage)
- second defense nonspecific
Reticular cells
Stationary APCs that contribute to connective tissue frame work of lymphatic organs
-second defense nonspecific
If bound to our particular antigen then starts deleting it and those like it
Primary immune response
Nonspecific, no prior exposure, skin (dry nutrient poor) and
mucous membranes(lysosomes destroys bacteria)
Sencondary immune response
Inflammation, fever and phagocytic cells, immune cells
Nonspecific
Third immune response
Specific
Prior exposure, protects against pathogens, vaccinations
Intracellular response
Virus ENTERS cell, cell kills virus then becomes a APCs informing other cells
Extracellular immune response
Bacteria is ENGULFED by a cell such as a macrophage and then becomes an APC
Interferons
Released form infected cell by virus, tells other cells not to make mRNA so it doesn’t reproduce
Tells cells to kill off infected host cells
MALT
External barrier
Mucous associated lymphatic tissue
GALT
External barrier
Gut associated lymphatic tissue
Cytokines
Small proteins that regulate inflammation and immunity (category)
Heparin
Pathogens are in a fluid pocket surrounded by clot
Prevents interference on damaged tissue
Chemotaxis
Leukocytes are attracted to chemtactic chemicals
Like EMTs, first responders
Monocytes
Clears out area where damage was made
MHC protein
-major histocompatiblaty complex
MHC 1 found on any nucleated cell intercellular pathogen (B cells T cells macrophages )
MHC 2 antigen presenting cell done extracelluar
Epitopes
are antigen determinants,
A place where antibodies bind themselves
7-8 amino acids long
Negative Selection
keeps it from circulating in blood stream and destroying our tissues
Interleukins
- chemical messenger of leukocytes
Cytotoxic cells
Cd8 cell, (cytotoxic T cell) carry out direct attack -MHC 1=8
Cd4 cells- are helper T cells, promotes t and B cell action (nonspecific defenses)
-MHC 2=8
