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Immunity > Lupus > Flashcards

Lupus Flashcards

1
Q

what triggers the onset of lupus

A

hormones (oral contraceptives, early onset menses, hormone replacement after menopause)

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2
Q

what can trigger lupus

A

exposure to some type of unknown virus, sunlight, UV light, or stress

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3
Q

discoid lupus

A

cutaneous, involves skin rash (may be butterfly or all over)

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4
Q

systemic lupus

A

attacks connective tissue, kidneys, and heart

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5
Q

drug induced lupus

A

can be caused by INH, thorazine (psych), apresoline (vasodilator), pronestyl (heart), and some anti-seizure meds

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6
Q

cause of anemia in lupus pts

A

during inflammatory process the body has a hard time replacing erythrocytes

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7
Q

swollen lymph glands in the area of rash

A

lymphadenopathy

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8
Q

sxs of pleural effusion

A

crackles, SOB, chest pain

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9
Q

C3 & C4 levels in lupus

A

decreased

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10
Q

BUN & creatinine in lupus

A

increased

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11
Q

urine: protein & RBC in lupus

A

positive

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12
Q

why do C3 & C4 go down

A

body can’t get rid of antigen/antibody complex

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13
Q

what helps bridge natural & acquired immunity

A

C3 & C4

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14
Q

pancytopenia

A

decrease in everything (WBC, platelet, RBC, etc)

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15
Q

sxs of pancytopenia

A

decreased cap refill, pallor, cold, blanchable

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16
Q

drugs for lupus (4)

A

NSAIDS, corticosteroids, immunosuppressants, anti-malarial

17
Q

what levels should be monitored for drug induced hepatitis

A

ALT & AST

18
Q

sxs of drug induced hepatitis

A

tired, lethargy, flu like sxs, N/V/D

19
Q

what do NSAIDS do for lupus pts

A

decrease inflammation

20
Q

what do corticosteroids do for lupus pts

A

decrease the inflammatory response

21
Q

tx for peptic ulcer

A

proton pump inhibitor (prevacid, prilosec, pepsid)

22
Q

what drug can cause peptic ulcer

A

corticosteroids

23
Q

immunosuppressives

A

Methotrexate (Rheumatrex)

Azathioprine (Imuran)

24
Q

side effects of immunosuppressives

A

alopecia, bone marrow suppression (formed elements of blood not made by bone marrow), increased infections, teratogenicity

25
Q

anti-malarial drug

A

hydroxychloroquine (plaquenil)

26
Q

use of plaquenil

A

changes pathway for immunity, decrease inflammation and joint pain

27
Q

anti-malarials should be taken with

A

NSAIDs

28
Q

side effects of Plaquenil

A

photosensitivity, visual changes (retinal detachment)

29
Q

cause of large holes in basement membranes of kidneys

A

lupus nephritis

30
Q

C3 & C4 levels are ___ in lupus nephritis

A

low

31
Q

sxs of lupus nephritis

A

dependent and periorbital edema, protein & RBCs in urine, increased BUN & creatinine

32
Q

sxs of peri/myocarditis

A

chest pain, fatigue, fever, arrhythmia, SOB

Immunity (4 decks)

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