Lung Cancer Wiki

Question 1

Most common symptoms of LC

Answer 1

Weight loss
Coughing up blood
SoB
Chest Pains

Question 2

85% of LC cases are due to

Answer 2

Smoking.

Question 3

LC diagnosis is aided by CXR and CT scans and confirmed by ____ via ________.

Answer 3

Biospy via bronchoscopy.

Question 4

Top 5 causes of LC

Answer 4

Smoking
Radon gas
Asbestos
Air pollution
Genetics - 8%, relatives of people with lung cancer have double to risk.

Question 5

Polymorphisms on chromosomes _, _ and __ are known to affect the risk of lung cancer.

Answer 5

5
6
15

Question 6

Mutations in the _-___ proto-oncogene are responsible for 10-30% of lung adenocarcinomas.

Answer 6

K-ras

Question 7

About 4% of non-small-cell lung carcinomas involve which fusion gene?

Answer 7

EML4-ALK tyrosine kinase.

Targeted via Crizotinib and Alectinib.

Question 8

NSCLC is composed of [3]

Answer 8

Adenocarcinoma
Squamous cell carcinoma
Large-cell carcinoma

Question 9

Most cases of SCLC arise where?

Answer 9

Larger airways, primary and secondary bronchi.

Question 10

TNM is based on

Answer 10

The size of the primary Tumour, lymph Node involvement and distant Metastasis.

Question 11

Surgery is really only used for

Answer 11

NSCLC

Question 12

For SCLC treatment, what is typically used?

Answer 12

Chemo and/or radiotherapy.

Question 13

For both NSCLC and SCLC patients, smaller doses of radiation to the chest may be used for what?

Answer 13

Symptom control, palliative radiotherapy.