Lung Cancer

Question 1

The most common type of lung cancer

Answer 1

Nonsmall Cell Lung Cancer

Question 2

Smoking is responsible for what percent of lung cancers in men?

Answer 2

80%

Question 3

The most common initial symptoms of lung cancer are

Answer 3

Cough, Dyspnea, Chest Pain or Discomfort, Hemoptysis

Question 4

The overall 5-year survival rate for all types of lung cancer is

Answer 4

22%

Question 5

What type of syndrome occurs more frequently with lung cancer than any other type of cancer?

Answer 5

Paraneoplastic syndromes

Question 6

The second leading cause of lung cancer is

Answer 6

Radon

Question 7

Paraneoplastic syndromes are most common with which type of lung cancer?

Answer 7

Small Cell Lung Cancer

Question 8

Paraneoplastic syndrome that results in changes in the areas under and around the toenails and fingernails

Answer 8

Clubbing

Question 9

The most common metastatic site for small call lung cancer is

Answer 9

Brain

Question 10

Which type of lung cancer has a slower growth rate and doubling time?

Answer 10

Nonsmall cell lung cancer

Question 11

The best strategy to prevent lung cancer

Answer 11

Smoking cessation

Question 12

High risk patients can be considered for screening with

Answer 12

Low-dose CT scan

Question 13

Poor prognosis associated with advanced lung cancer is due to

Answer 13

Advanced disease at time of diagnosis

Question 14

Chemoprevention is

Answer 14

The use of prophylactic medications to prevent the development of cancer

Question 15

Older people who smoke and take a beta-carotene supplement have an ________ risk of developing lung cancer.

Answer 15

Increased

Question 16

In which type of cancer should have the tissue undergo analysis for PD-L1 and genetic mutations?

Answer 16

Nonsmall Cell Lung Cancer

Question 17

Advanced small cell lung cancer has a 5-year survival rate of l ______%

Answer 17

6%

Question 18

The majority of small cell lung cancer presents as ___________ disease.

Answer 18

Extensive

Question 19

The mainstay of treatment in local small nonsmall cell lung cancer is

Answer 19

Surgery

Question 20

Locally advanced NSCLC may be treated with

Answer 20

Surgery, Neoadjuvant or Adjuvant Chemotherapy, Radiation

Question 21

Advanced NSCLC is treated based the whether the tissue expresses

Answer 21

PD-L1 or genetic mutations

Question 22

First-line therapy for patients with NSCLC with PD-L1 tumors is

Answer 22

Pembrolizumab

Question 23

Pembrolizumab belongs to which class of medications

Answer 23

Immune checkpoint inhibitor

Question 24

First-line treatment for patients with advanced NSCLC that harbor an EGFR mutation should be treated with

Answer 24

Osimertinib

Question 25

First line treatment for patients with nonbiomarker driven metastatic NSCLC is

Answer 25

Chemotherapy and PD-L1 directed therapy

Question 26

First-line chemotherapy for NSCLC includes combination therapy with

Answer 26

A platinum-based doublet

Question 27

The mainstay of treatment of limited disease SCLS is

Answer 27

Radiation and chemotherapy

Question 28

The primary chemotherapy regiment used in the treatment of SCLC

Answer 28

Etoposide and Cisplatin (or Carboplatin)

Question 29

Carboplatin + etoposide + atezolizumab is the new first line treatment for

Answer 29

Extensive stage SCLC

Question 30

Durvalumab

Answer 30

Used for consolidation therapy for limited stage NSCLC

Question 31

Mutations that may occur in advanced stage NSCLC include

Answer 31

EGFR, ALK, ROS-1, BRAF

Question 32

Osimertinib is the preferred agent to target

Answer 32

EGFR-mutation positive tumors

Question 33

Common adverse effects of Osimertinib include

Answer 33

Diarrhea, stomatitis, dermatologic reactions, anorexia, fatigue, myelosuppression

Question 34

Monitoring parameters for Osimertinib includes

Answer 34

Chemistry, CBC, eye exams, ECG, EF, and S/S of lung disease

Question 35

Atezolizumab belongs to which class of medications

Answer 35

PD-L1 Inhibitor

Question 36

Etoposide belongs to which class of chemotherapeutic agents.

Answer 36

Topoisomerase Inhibitors

Question 37

The primary adverse effects of platinum chemotherapy include

Answer 37

Nausea, vomiting, myelosuppression, electrolytic abnormalities, nephrotoxicity, peripheral neuropathy, and ototoxicity

Question 38

The primary adverse effects of etoposide include

Answer 38

Myelosuppression, hair loss, mucositis, anorexia, diarrhea, metallic taste, low BP (if infused too fast)

Question 39

Which chemotherapy agent used to treat NSCLC should not be given to patients with squamous cell carcinoma?

Answer 39

Pemetrexed

Question 40

Which monoclonal antibody can cause fatal hemoptysis when given to patients with Squamous Cell NSCLC

Answer 40

Bevacizumab