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MS3 - Respiratory > Lung Cancer > Flashcards

Lung Cancer Flashcards

1
Q

Main classification of lung cancer?

A

small-cell

non-small-cell

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2
Q

Non small cell carcinoma examples?

A

Squamous cell carcinoma,
adenocarcinoma
large-cell

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3
Q

RFs for Squamous cell carcinoma of lung M:F?

A

M>F
smoking
radon gas

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4
Q

Squamous cell carcinoma site?

A

central near bronchi

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5
Q

Squamous cell carcinoma ectopic hormone

A

PTHrP → ↑ Ca2+

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6
Q

Adenocarcinoma RFs?

A

F>M
non-smoker,
far east

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7
Q

Adenocarcinoma site

A

peripheral

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8
Q

Large cell carcinoma site

A

Central or peripherally located

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9
Q

Differentiation level of non- small cell carcinoma

A

Squamous cell carcinoma (squamous)
adenocarcinoma (glandular)
large-cell (poorly differentiated)

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10
Q

Small cell carcinoma site

A

central near bronchi

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11
Q

Small-cell carcinoma differentiation

A

poorly differentiated

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12
Q

Small-cell carcinoma prognosis

A

very chemo sensitive, poor prognosis though

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13
Q

Complications of lung cancer?

A 
Recurrent laryngeal N. palsy
Phrenic N. palsy
SVC obstruction
Horner’s (Pancoast’s tumour)
AF
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14
Q

Endocrine complications of lung cancer?

A
  • ADH → SIADH ( euvolaemic ↓Na+)
  • ACTH → Cushing’s syndrome
  • Serotonin → carcinoid (flushing, diarrhoea)
  • PTHrP → 1O HPT (↑Ca2+, bone pain)
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15
Q

Non-small cell lung carcinoma management?

A
  1. Surgical Resection
  2. Curative radiotherapy
  3. Chemo ± radio for more advanced disease
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16
Q

Small cell carcinoma of lung management?

A

Palliation

  1. Radio: bronchial obstruction, haemoptysis, bone or CNS mets
  2. SVC obstruction: stenting + radio + dexamethasone
  3. Endobronchial therapy: stenting, brachytherapy
  4. Pleural drainage
  5. Analgesia
17
Q

Prognosis of small cell

A

1-1.5yrs median survival treated; 3mo untreated

18
Q

Prognosis of non-small cell

A

50% 5ys w/o spread; 10% ̄c spread

MS3 - Respiratory (9 decks)

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