Lung cancer

Question 1

who gets more squamous cell carcinoma

Answer 1

men

Question 2

who gets more adenocarcinoma

Answer 2

women

Question 3

keratinization
intercellular bridges
central or hilar lesions
CAVITATION

Answer 3

Squamous cell

Question 4

precursor lesion to sqamous cell

Answer 4

squamous metaplasia
dysplasia
of bronchial epithelium

Question 5

peripheral lesion
non smoker or smoker
glandular lesion

Answer 5

adenocarcinoma

Question 6

precursor lesion to adenocarcinoma

Answer 6

bronchioalveolar carcinoma

atypical denomatous hyperplasia

Question 7

CENTRAL lesion
small cells
scant cytoplasm
numerous mitoses
necrosis
neuroendocrine

Answer 7

small cell carcinoma

Question 8

central or peripheral
patients < 40
neuroendocrine
nests of uniform cells

Answer 8

carcinoid- typical or atypical

Question 9

gene mutations in small cell

Answer 9

kit
p53, bcl-2, Rb, myc
increased telomerase

Question 10

gene mutations in non small cell

Answer 10

EGFR

kras, p53, p16

Question 11

Primary mutations in adenocarcinoma

Answer 11

EGFR, kRas

Question 12

Similar mutation frequency in adeno and sqamous

Answer 12

p53, p16

Question 13

paraneoplastic syndrome most commonly seen with adenocarcinoma

Answer 13

hypertrophic osteoarthropathy

Question 14

Malignancy calcifications include

Answer 14

STIppled

Eccentric

Question 15

Benign calcifications

Answer 15

diffuse
central
popcorn
laminated

Question 16

if the tumor doubles between 20-400 days this is consistent with

Answer 16

malignancy

Question 17

if doubling time is less than 20 days

Answer 17

more likely benign

inflammatory

Question 18

which lesions will be positive for FDG PET

Answer 18

malignancy
inflammatory
infectious lesions

Question 19

treatment of choice for stage 1-2 nonsmall cell lung cancer

Answer 19

Surigical resection

Question 20

small cell lung cancer treatment

Answer 20

chemo and some radiation if confined to ipsilateral hemithorax