Lung Cancer Flashcards
in terms of the subtypes of lung CA, there has been something of a change in Australia
which subtypes are becoming less frequent, and which are more?
which subtype has the highest rates of disease in non-smokers?
AdenoCA is increasing. Possibly thought related to the filters in cigs, and possibly increased nitrates (no idea where this came from)
SCC and SCLC are decreasing.
AdenoCA is the subtype most associated with non-smokers.
there is a new adenocarcinoma classification.
what is the rationale behind this, and what are the majorly bad things that can happen with some treatments of squamous cell CA?
wow that was a circuitous question.
adenoCA and unspecified NSCLC should be tested for EGFR and other mutations
there is a potential life threatening haemorrhage associated with SQUAMOUS cell in patients who receive bevacizumab
which of the lung cancers are considered neuroendocrine tumours?
Small cell lung CA should be considered such. They have neuroendocrine granules and secrete peptides like NSE, GRP-bombesin and chromogranin A
This neuroendocrine nature is possibly why they are so associated with paraneoplastic
carcinoid is also a lung cancer subtype.
what is the antibody typically associated with lung CA paraneoplastic syndromes?
sensory, motor, autonomic, encephalomyelitis leading to anti-HU antibodies
can also get ELMS with anti-calcium channel
what is the difference between bronchoscopic biopsy and EBUS?
the EBUS can be a tiny little probe that we can use to get through smaller airways. The US component allows us to have greater certainty about the location of the biopsy
bronchoscopy usually has a video camera in the probe, which makes it a bit bigger.
note: “ultrathin scope” is being developed and may change this paradigm
which type of lung cancer is most associated with SIADH?
that would be small cell, typically
if a gentleman with small cell has sudden onset severe back pain, but no neurology, THEN gets an MRI which shows lesions in the spine, what is the next treatment?
because this is small cell, the college wants us to think about chemo as a first line.
perhaps if there was cord compression then you would look first at surg/XRT
