lung cancer

Question 1

prognostic vs predictive biomarkers

Answer 1

prognostic(increased risk of relapse): tells us outcome (survival) based on natural course of disease without therapeutic intervention. Predictive (who will benefit from therapy): outcome based on specific therapy

Question 2

status of lung cancer screening

Answer 2

low-dose CT led to 20% reduction in lung cancer mortality

Question 3

EGFR/HER2 mutation

Answer 3

treated with tyrosince kinase inhibitors (internal) and monoclonal antibodies (external). biomarkers by FISH, protein expression and

Question 4

Anaplastic lymphoma kinase

Answer 4

biomarkers: fluorescent in situ hybrid, ALK-expression, FISH. ALK close to EML4. can get fusion gene EML4-ALK via rearragement. Get ALK-treatment