LS6003 TB1 Antibacterial chemotherapy

Question 1

fill in

Answer 1

Question 2

what is the main difference between gram postive/negative bacteria and acid fast bacteria

Answer 2

+ = thick peptidoglycan outer layer
- = thin peptidoglycan (periplasm), contains outer membrane endotoxins
acid fast = waxy mycolic layer, makiing them difficult to penetrate and therefore treat

Question 3

give an examle of acid fast bacteria

Answer 3

TB

Question 4

Answer 4

Question 5

Answer 5

Question 6

what is the main class 2 reaction found in prokaryotes?

Answer 6

Folate synthesis
Only fungi, bacteria and plants can synthesise folate. Animals acquire through diet.

Question 7

What are the 3 main class 3 reactions found in prolaryotes, in order of viability to attack with antimicrobials.

Answer 7

peptidoglycan synthesis(easiest method of attackin bacteria as they are dividing at this point)
protein synthesis
Nucleic acid synthesis

Question 8

what is the best phase in the bacteria population growth curve, to attack bacteria?

Answer 8

exponential phase, with something that interupts peptidoglycan production.

Question 9

`in what stage of the bacteria population growth curve does the physiology of cells start to change, and ‘antibiotics’ start being produced by the bacteria?

Answer 9

stationary phase, to kill of competition

Question 10

what are some of the characterisitcis of a bacteril spore?

Answer 10

dormant until germinated, vrey hard to remove as completely dehydrated/inactive, only vunerable(able to be attackd) when germinated

Question 11

agents that kill are known as ?
agents that inhibit are known as?

Answer 11

cidal
static

Question 12

is human sensitivity to antibiotics more or less variable than microbial sensitivity?

Answer 12

human sensitivity to antibiotics is less variable than microbial sensitivity

Question 13

what are the 2 conditions that must be met for an antibiotic to be classed as ‘effective’

Answer 13

-achievable concentration at site of infection for a significant period of time during treatment
-concentration must be higher than minimum inhibitory concentration

Question 14

what are the 5 factors associated with effective concentration

Answer 14

-route of admin orf antiobiotic
-distribution around body tissue
-extent of binding to plasma proteins
-rate and route of exretion
-number and staging of doses

Question 15

define antimicrobial chemotherapy

Answer 15

the use of antimicrobial chemicals to treat and cure infectious diseases

Question 16

define antimicrobial chemotherapeutic agent

Answer 16

a chemical used in chemotherpay, commonly reffered to as antibiotics