LPs from on track Flashcards

1
Q

Which class of ABs is associated with dental hypoplasia in children U12 therefore contraindicated?

A

Tetracyclines

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2
Q

Why is aspirin contraindicated in U16s? (Unless it’s for Kawasaki’s disease)

A

Risk of Reye’s syndrome

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3
Q

Which bisophosphonate is contraindicated in women of child bearing age?

A

Zolendronic acid

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4
Q

Alcohol + sulphonylureas?

A

Enhanced anti diabetic effect

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5
Q

Long term bisphosphonate therapy is associated with what?

A

Atypical femoral fractures

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6
Q

What is dermatophytic onychomycosis?

A

Fungal infection of nails

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7
Q

If you do not use GTN tablets wihin how many weeks of first opening bottle then discard and obtain fresh supply?

A

8 weeks

(GTN tablets are administered by putting them under tongue, may be repeated at 5 min interval. If pain persists for more than 15 min, medical care should be sought)

(Should not be transferred to another container)

(Preferably taken when sitting down)

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8
Q

Which of the following do not cause rectal bleeding?

Anal fissure 
Colorectal carcinoma 
Diverticular disease 
Hiatus hernia
Inflammatory bowel disease
A

Hiatus hernia

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9
Q

Vitamin D is responsible for the absorption of calcium therefore increasing serum calcium. What are signs of hypercalcaemia?

A

N + V

Loss of appetite

Constipation and abdominal pain

Increased thirst and frequent urination

Fatigue, weakness and muscle pain

Confusion, headaches and depression

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10
Q

Baclofen can enhance the hypotensive effects of ACEi and BBs. What’s its main indication?

A

Relief of spasticity of voluntary muscle resulting from MS, spinal cord and motor neurone diseases.

(Can cause hallucinations)

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11
Q

Which anticoagulant should be avoided in pregnancy?

A

Vitamin K antagonists

Warfarin, phenindione

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12
Q

Which laxative agent can interfere with fat soluble vitamins?pp

A

Liquid paraffin

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13
Q

Atovaquane is licensed for the treatment of mild to moderate pneumocystis infections who can’t tolerate co-trimoxazole. What are options for severe pneumocystis?

A

Hydrocortisone

Pentamidine isetionate

Prednisolone

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14
Q

Xylometazoline 0.1 nasal spray and other otc sympathomimetics should be used for how long and why?

A

No more than 7 days

Can cause rhinitis medicamentosa

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15
Q

Paracetamol with pts who weigh under 50 kg

A

Use with caution

Increased risk of toxicity

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16
Q

Sensitivity to sulphonamides + triptans

A

Use with caution

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17
Q

Laxative choice for terminally ill

A

Co-danthramer

Dantor (stimulant laxative)

Ploxamer 188 (wetting agent that acts as a stool softener)

May colour urine red

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18
Q

Docusate sodium

A

Osmotic + stimulant propeties

500 mg daily in divided doses

Adult patients suffering from chronic constipation

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19
Q

Lactulose

A

Osmotic laxative

Used in hepatic encephalopathy

Opioid induced constipation (can also stimulant but avoid bulk forming)

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20
Q

Mycophenolate Mofetil counselling points regarding contraception.

(Immunosuppressant following transplant)

A

Males: Both partners should use appropriate contraception during treatment and for at least 90 days after stopping.

Females: use 2 types of contraception for up to 6 weeks after stopping treatment

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21
Q

Difference between German measles (rubella) and measles (morbilli)

Ps rubella can cause organ damage during early stages of pregnancy (CRS)

A

Measles manifests itself with white spots (surrounded by red ring) on inner cheek and gums

NB. Rubella (German measles) becomes a serious concern if a pregnant woman catches it within first 20 weeks of pregnant. Can disrupt development of baby.

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22
Q

Which jab is given at 8 weeks 12 weeks and 16 weeks during first year of life?

A

Single jab containing vaccines to protect against sis separate diseases:

Diphtheria 
Tetanus
Whooping cough (pertussis)
Polio 
H. Influenzae type b
Hib and hepatitis B
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23
Q

Ergotamine contraindications

A

Inadequately controlled hypertension

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24
Q

Benzodiazepines contraindications

A

Acute pulmonary insufficiency

Marked neuromuscular respiratory weakness

Sleep apnoea syndrome

Unstable myasthenia gravis

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25
Ganciclovir contraindications
Abnormally low haemoglobin count Low neutrophil count Low platelet count
26
Zonisamide counselling points
Avoid factors which cause overheating or dehydration like exercise.
27
Drugs that cause gingival hyperplasia (swollen gums)
Ciclosporin Antiepileptics (not valproate) CCBs
28
Hydroxychloroquine Report if:
Visual symptoms. Ocular toxicity is possible
29
What effect does buprenorphine have on other opioids?
Antagonises their analgesic effects.
30
Bethamethasone valerate/clioquinol cream could stain clothing
.
31
What’s in codis and tramacet?
Codis: codeine and aspirin m Tramacet: tramadol and paracetamol
32
Risks associated with antipsychotics
``` Hypothermia Hyperthermia Postural hypotension Hyperglycaemia Stroke ```
33
Colestyramine is contraindicated in
Complete biliary obstruction (won’t be effective)
34
Ursodeoxycholic acid is contraindicated in
Acute inflammation of the gall bladder
35
Subcutaneous haemotoma can be a result of?
Dalteparin injection site reaction
36
Pizotifen indication?
Migraine prophylaxis
37
Common side effects of isotretonin?
Skin thinning Dry skin Chapped lips and skin (Stay away from sun)
38
Hydroxyzine main indications
Pruritus (lowest effective dose shortest possible duration) Assist in the management of anxiety (Piperazine derivative antihistamine with antimuscuranic and sedative properties)
39
Gradual withdrawal of steroids should be consider when dose exceeds?
Prednisolone 40 mg daily or equivalent for more than 1 week Also if received more than 3 weeks treatment Also if there’s other possible causes of adrenal suppression and
40
Chloramphenicol 10 ml OTC for bacterial conjunctivitis can be used to a maximum duration of:
5 days
41
‘Asbestos-like’ scales on scalp?
Pityriasis amiantacea
42
Phenytoin + miconazole
Miconazole enhances anticonvulsant is effect of phenytoin (lower risk with topics preparation)
43
Avoid clarythromycin in breast feeding
.
44
Lithium + Candesartan
Candesartan potentially increases conc of lithium throughan unknown mechanism. Adjust dose and monitor
45
What vaccine is used for the prevention of cervical cancer?
Human Papilloma Virus vaccine (HPV) | Especially in young children
46
Red scaly patches typically affecting central regions of face, eye brows and scalp?
Seborrhoeic dermatitis
47
Valganciclovir
Potential teratogen and carcinogen. Caution is advised when handling. Wash off immediately if come in contact
48
Which has a higher risk of GI bleed clopidogrel or alendronic acid?
Clopidogrel
49
HRT should be stopped (pending investigation) if patient experiences
Severe stomach pain
50
High doses of all corticosteroids is associated with Cushing’s syndrome. What are the symptoms?
Moon face Facial acne Stria (stretch marks)
51
As well as hypokalaemia wha else can thiazide like diuretics induce?
Hyperuricaemia
52
Termination of pregnancy following mifepristone?
Misoprostol
53
Induction of labour for medical reasons
Oxytocin
54
Risk of osteonecrosis of the jaw particularly IV
Bisphosphonates
55
Benzodiazepines antidote?
Flumazenil
56
Lamotrigine can also cause anaemia bruising infection and signs of bone marrow suppression
.
57
This drug is associated with post-menopausal bleeding as a side effect
Spironolactone
58
Acute Porphyria
Fluconazole and progesterone contraindicated in this condition
59
Citalopram + sildenafil
QT prolongation
60
Isosorbide + amlodipine + lisinopril
Potentiate first dose hypotension
61
BB + digoxin
Bradycardia
62
Early treatment with what can delay need for levodopa therapy?
Selegiline | Hair loss is a side effect
63
Amantadine is cautioned in?
Congestive heart failure as it may exacerbate oedema
64
Check LFTs prior amiodarone or statin?
Statin
65
Mydrasis
Dilation of pupil. | Antimuscuranic side effect
66
Dopamine agonists are associated with?
``` Binge eating Excessive daytime sleeping Hallucinations HYPOtensive reactions Fibrotic reactions ```
67
Medicine reconciliation process
Creating an accurate list of a patients current medication and comparing this to those in the PMR with the goal of providing the patient with the correct medication
68
Influenza vaccination is recommended in
All pregnant women
69
Can stop taking iron how many weeks after haemoglobin levels back to normal?
12
70
Transiminase enzymes is a measure of?
Liver function If they’re raised then liver is damaged
71
Ramipril should not be given in the second and third trimester if pregnancy
.
72
Atenolol is contraindicated in intestinal ulcer
.
73
Which antimalarial is contraindicated in history of psychiatric disorders?
Mefloquine
74
Antiemetic choice in radiotherapy
Dexamethasone
75
Impetigo treatment
Fucidic acid Flucloxacillin
76
Which EGFR inhibitor is not associated with keratitis and ulcerative keratitis leading to corneal perforation and blindness?
Ofatumumab Cetuximab, Erlotinib, Gefitinib, and panitumumab all cause it.
77
Mineralocorticoid Side effects | Fludrocortisone (postural hypotension, addisons disease)
``` Hypertension Sodium retention Water retention Potassium loss Calcium loss ```
78
Glucocorticoid side effects
Diabetes Osteoporosis Avascular necrosis Possibly peptic ulceration and psychiatric reactions
79
Tiamterene + potassium supplements
synergistic effects (Tiametrene is a potassium conserving drug)