Lower Respiratory Tract Infections Flashcards

1
Q

List the defence mechanisms of LRT.

A
Mucus
Cilia
Swallowing, coughing, sneezing
Alveolar macrophages and lymphoid tissue
Immunoglobulin A
Normal flora bacteria - G+ - streptococci, staphylococci
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2
Q

Describe acute bronchitis

A

Acute inflammation of the bronchial tree leading to a cough.
Cough can last 3 weeks.
Absence of pneumonia.
Usually self-limiting.

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3
Q

Symptoms of acute bronchitis is caused by the acute inflammation of the bronchial tree. What are these symptoms?

A

Increased mucus production
Oedema of the bronchus
Cough
Wheeze
May have temperature
Infection may be cleared but repair of bronchial wall takes weeks hence patient may still have cough
Pulmonary function tests show bronchial obstruction seen in asthma but will return to normal

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4
Q

What are some self-care treatment options for acute bronchitis?

A
Honey and lemon
Pelargonium
Paracetamol/ibuprofen
OTC expectorant - guaifenesin
OTC antitussive/cough suppressant - pholcodine
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5
Q

Describe community acquired pneumonia.

A

Acute infection of the lung parenchyma caused by bacteria or virus. Causes localised collapse and consolidation of alveolar sacs causing impaired gas exchange.

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6
Q

What are the complications of community acquired pneumonia?

A

Pleural effusion - build up of excess fluid between pleural membrane and lungs.
Lung abscesses - pus-filled cavity in your lung surrounded by inflamed tissue.
Acute respiratory disease syndrome (ARDS) - life-threatening lung injury that allows fluid to leak into the lungs.
Septic shock - dangerous drop in blood pressure.

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7
Q

What are the 8 risk factors for developing community acquired pneumonia?

A
Age = >65
Residence in healthcare setting
COPD
Smoker/exposure to cigarette smoke
Alcohol abuse
Poor oral hygiene 
Contact with children
Use of acid regulating drugs
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8
Q

What are the symptoms (7) of community acquired pneumonia?

A
Dyspnea - shortness of breath
Sputum production - maybe mucopurulent 
Pleural pain - sharp chest pain
Sweating 
Fevers 
Rigors - shivering
Aches and pains
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9
Q

What should be monitored in hospital acquired pneumonia?

A

Monitor pulse, BP, Respiratory Rate, temperature, oxygen saturation, mental status, CRP (if no improvement in 48-72hours).

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10
Q

Describe bronchiolitis.

A

Viral infection predominately caused by respiratory syncytial virus.
Causes inflammation of the epithelial lining of the bronchial tree.
Infected epithelial cells slough off into the small airways leading to partial or complete collapse or obstruction of the airways.
Results in impaired gas exchange.

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11
Q

What are the emergency/urgent signs of severe bronchiolitis in children?

A
Apnea
Child looks very unwell
Severe respiratory distress
Respiratory rate >70 breaths/min 
Central cyanosis
Sats <90% on room air or <92% if <6weeks old or underlying co-morbidities.
(Sats = O2 saturation)
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12
Q

How to tell if bronchiolitis is getting severe in children?

A
Agitation and reduced consciousness
Exhaustion
Cyanosis
Use of accessory muscles of breathing at rest
Dehydration
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13
Q

In what cases is an immediate or backup antibiotic prescription given?

A
  • patient systemically very unwell
  • pre-existing co-morbidity
  • young children born prematurely
  • > 65 with 2 of the following or >80 with 1 of the following:
    hospital admission in previous year, Type 1/2 diabetes history of congestive heart failure, use of oral corticosteroids, if CRP levels high.
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14
Q

What are the 6 signs of community acquired pneumonia?

A
  • Patient will be moderately to severely ill.
  • Focal chest signs such as decreased/asymmetric breath sounds.
  • High temperature.
  • May be hypoxic.
  • Confusion (esp in older patients)
  • Abnormal chest x-ray
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15
Q

What is CRB-65?

A

A tool used in community/primary care to assess severity of CAP in adults.
CONFUSION - new disorientation in person.
raised RESPIRATORY rate - >30 breaths/min (normal = 12-18)
low BLOOD pressure - diastolic <60mmHg or systolic <90mmHg
age = >65

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16
Q

What do the scores mean when using CRB-65?

A

0 = low risk of death
1-2 = intermediate risk of death
3-4 = high risk of death
(above 2 = hospital)

17
Q

What does NICE recommend for all patients transferred to hospital?

A

Recommends that diagnosis confirmed with chest x-ray and treatment done within 4 hours of presentation at AandE.
Calculate CURB-65 score.
Check patients CRP, LFT and FBC.

18
Q

What is CURB-65/

A

A tool used in hospital to assess the severity of CAP.
CONFUSION - new disorientation in person
blood UREA nitrogen level > 7mmol/mol
raised RESPIRATORY rate - >30 breaths/min (normal = 12-18)
low BLOOD pressure - diastolic <60mmHg or systolic <90mmHg
age = >65

19
Q

What do the scores mean when using CURB-65?

A

0-1 = low risk of death
2 = intermediate risk of death
3-4 = high risk of death
(above 3 = ICU needed)

20
Q

What is hospital acquired pneumonia?

A

Acute LRT infection acquired after at least 48 hours of admission to hospital with no history of intubation.
Symptoms at day 1 or 2 of admission = CAP.
Affects those in ICU, major surgery or prolonged stay.

21
Q

What are the causative organisms for HAP?

A
Early onset (<5 days post adm) = streptococcus pneumoniae
Late onset (>5 days post adm) = acquired in hospital - MRSA, pseudomonas aeruginosa, non-pseudomonal G- bacteria.
22
Q

What are the risk factors for HAP?

A
  • poor infection control/hand hygiene
  • aspiration (drawing fluid out of body)
  • multi drug resistant bacteria
  • intubation and mechanical ventilation
23
Q

What are the signs and symptoms of HAP?

A
Fever >38 degrees
Leukocytosis or leukopenia 
Purulent sputum
Decline in oxygen saturation
Cough, dyspnea, chest pain, malaise anorexia 
Tachycardia
Decreased lung resonance
Asymmetrical chest expansion
Abnormal chest sounds
24
Q

What tests are required to be carried out for HAP?

A
Measure oxygen saturation
Chest x-ray
FBC
Blood gases
CRP
Renal function and LFTs
Sputum cultures
25
Q

How is covid pneumonia diagnosed?

A
  • Temperature >38
  • Respiratory rate >20 breaths/min
  • Heart rate above 100 bpm
  • New confusion
  • CRB65 not valid in covid
  • Antibiotics prescribed if secondary bacterial infection is suspected
26
Q

Outline the primary and secondary prevention for pneumonia.

A

Primary

  • Vaccinations - influenza annually and one off pneumococcal vaccine unless splenic dysf or chronic renal disease - should be done every 5 years.
  • Covid-19 vaccinations.
  • Smoking cessation.

Secondary

  • Reinforce vaccinations.
  • Smoking cessation.
27
Q

What is the prognosis of bronchiolitis?

A

Self-limiting condition

Usually last 3-7 days with cough resolving in 3 weeks in most patients.

28
Q

In what groups of children can bronchiolitis cause severe infection?

A
Chronic lung disease
Congenital heart disease
Neuromuscular disorders
Immunodeficiency
<3 months old
Premature
29
Q

How is bronchiolitis in children diagnosed?

A

Suspect in children under 2 presenting with:
- coryzal prodromal phase lasting 1-3 days and cough with:
tachypnea (shallow and fast breathing)
chest recession (air not flowing freely through lungs)
wheeze or crackles on chest auscultation

30
Q

What are some general bronchiolitis symptoms in children?

A

Fever
Poor feeding
Apnea
Increased respiratory rates

31
Q

What symptoms of bronchiolitis indicates that child should be referred to hospital?

A
Respiratory rate >60 breaths per min
Taking only 50-75% of usual fluid
Clinically dehydrated
Oxygen saturation persistently <92%
Underlying co-morbidities
32
Q

What injection is given to prevent serious lung infection in children caused by RSV virus?
(RSV = respiratory syncytial virus)

A

Palivizumab

  • monoclonal antibody
  • Synagis is the brand