Lower GI Pharmacology - French

Question 1

RECALL: Drugs that are associated with constipation as a side effect (5 classes)

Answer 1

1) Calcium channel blockers (esp. verapamil)
2) Opioid analgesics
3) Antimuscarinic agents plus drugs with antimuscarinic side effects (tricyclic antidepressants, antipsychotic agents, 1st generation antihistamines, parkinsonian agents)
4) Aluminum and calcium-containing antacids plus calcium supplements (esp. carbonate)
5) Chemotherapeutic vinca alkaloids

Question 2

Psyllium Seed. MOA, brand name, indication

Answer 2

Laxative

Metamucil, fiber/bulk forming agent.

Question 3

Mg(OH)2

Answer 3

Laxative

Saline (osmotically-active) cathartics, Milk of Magnesia

Question 4

Polyethylene glycols

Answer 4

Laxative

Miralax, Saline (osmotically-active) cathartics

Question 5

Bisacodyl

Answer 5

Laxative

Stimulant / irritant

Question 6

Docusate

Indication, class

Answer 6

Laxative

Wetting agents / emollients

Question 7

Loperamide.

Indication, class.

Answer 7

Antidiarrheal

Opioid

Question 8

Polycarbophil

Indication, class.

Answer 8

Antidiarrheal

Opioid

Question 9

Bismuth subsalicylate

Indication, trade name.

Answer 9

Antidiarrheal, absorbent agent

Pepto Bismol

Question 10

Kaolin / Pectin

indication, class

Answer 10

Antidiarrheal, absorbent agent

Question 11

Name two drugs for IBS.

Answer 11

Tegaserod

Alosetron.