low yield Flashcards
1
Q
What is fibrillary-immunotactoid glomerulopathy?
A
Very rare condition causing a wide variety of histologic lesions
Resulting from glomerular accumulation of fibrils that aren’t amyloid
- don’t stain positive on congo red
Half develop renal failure and there’s no consensus on treatment
2
Q
What are AA, ATTR, AF, and AB2GP amyloidoses?
A
- *AA = serum amyloid A protein**
- Associated with chronic inflammatory states
- Improves with treatment of the underlying inflammation
- Usually begins with the kidneys; then liver, spleen, nerves. rarely heart.
- *ATTR = transthyretin**
- familial and wild type. Familial rare. Wild type increasingly found in autopsy in the old
- familial ATTRm mutation present in 3-4% of afro-caribbeans
- Vitreous amyloid deposits pathognomonic
AB2GP
- Rheumatologic manifestations in those on long term haemodialysis
- Less common with modern high-flux membranes
- Carpal tunnel, effusions, cystic bone lesions
