location and function of stem cell niches Flashcards
Where are stem cells found in the adult body?
Stem cells are found in various tissues, including bone marrow, skin, and liver, where they play a role in regeneration and repair
What is a stem cell niche?
A stem cell niche is the specific location within a tissue where stem cells are found. It provides a unique microenvironment that regulates their activity.
What are the key functions of a stem cell niche?
A stem cell niche must maintain the stem cells in an inactive and undifferentiated state for long periods and also support their rapid proliferation and differentiation when needed.
How do stem cells in striated muscle behave in response to injury?
In striated muscle, stem cells remain inactive until muscle injury occurs. Changes in the niche stimulate them to proliferate and differentiate to replace damaged tissue, contributing to muscle regeneration.
What is an example of a stem cell niche that promotes continuous proliferation and differentiation?
Bone marrow and hair follicles are examples of niches where the microenvironment supports continuous stem cell proliferation and differentiation.
Why are stem cell niches of interest in regenerative medicine?
Stem cell niches are of great interest because if we can stimulate these niches outside the body, it may be possible to generate human tissues in vitro for use in restorative surgery and regenerative medicine.
