Locally advanced, Inflammatory and others

Question 1

locally advanced breast cancer include

Answer 1

large primary tumors (>5 cm)
tumors involving the chest wall
skin involvement
ulceration or satellite skin nodules
inflammatory carcinoma
bulky or fixed axillary nodes
clinically apparent internal mammary
or supraclavicular nodal involvement
(stages IIB, IIIA, and IIIB disease).

Question 2

inflammatory breast cancer

Answer 2

• The hallmark of inflammatory breast cancer is diffuse
  tumor involvement of the dermal lymphatic channels
  within the breast and overlying skin, often without a
  discrete underlying tumor mass.
• may be no abnormality on mammography beyond skin
  thickening
• palpable mass is not required for the diagnosis

Question 3

inflammatory breast cancer presentation

Answer 3

• rapid onset of the disease, with progression over
  weeks to 3 months.
• Clinical Diagnosis
• pathologic hallmark :
  » tumor cells within dermal lymphatics
• ALND always performed
• Tx :
  neoadjuvant chemotherapy
  mastectomy
  radiation therapy
  endocrine therapy for ER-positive tumors
  trastuzumab for HER-2–positive tumors

Question 4

Relapse free Survival

Answer 4

50% or higher at 5 years