Local Vs Systemic Cytokine Effects Flashcards
IL-I beta
Local effect
Activates vascular endothelium
Activates lymphocytes
Local tissue destruction
Increases access of effector cell
IL-1 beta systemic effects
Fever
Production of IL-6
TNF-alpha
Local effect
Activates vascular endothelium and increases vascular permeability which leads to increased entry of IgG, complement, and cells to tissues and increased fluid drainage to lymph node
TNF-alpha
Systemic effect
Fever
Mobilization of metabolites
Shock
IL-6
Local effects
Lymphocyte activation and increased antibody production
IL-6
Systemic effects
Fever
Induces acute-phase protein production by hepatocytes
IL-8
Local effect
Chemotactic factor recruits neutrophils, basophils, and T cells to site of infection
IL-12
Local effect
Activates NK cells
Induces the differentiation of CD4 T cell into T(small H)1 cells
Helps breach innate and adaptive immunity
