Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Anesthesia Pharm COPY of Andy's > Local Anesthetics - Part II > Flashcards

Local Anesthetics - Part II Flashcards

1
Q

What is the average pKa of local anesthetics?

A

8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the function of the Alkalinization of LA Solutions?

What are the benefits of alkalinization?

A

Alkalinization increases the percentage of lipid-soluble or non-ionized forms.

Benefits:
* Faster onset of action
* ↑ Onset Peripheral and epidural blocks by 3 to 5 mins.
* Enhances the depth
* Increase the spread (i.e., epidural)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

If Drug V (weak base) has a pKa of 9.1, will the drug be more ionized or nonionized at physiological pH?

A

pKa - pH
9.1 - 7.4 = +1.7

Drug V will be more ionized at physiological pH.

Weak Bases, pKa before pH
Weak Acids, pKa afterpH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

If the pKa of LA (a weak base) is at 4.5, will the drug be more ionized or nonionized at physiological pH?

A

pKa - pH
4.5 - 7.4 = -2.9

LA will be more non-ionized at physiological pH.

Weak Bases, pKa before pH
Weak Acids, pKa afterpH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

LA1’s pKa is 9.2, and LA2’s pKa is 7.5. Which of the following are correct when placed in physiological pH? Select 2 answers.

A. LA2 has more non-ionized components
B. LA1 has more ionized components
C. LA2 has more ionized components
D. LA1 has more non-ionized components

A

B and C

LA1
9.2 - 7.4 = +1.8 (ionized)

LA2
7.5 - 7.4 = +0.1 (ionized)

Weak Bases, pKa before pH
Weak Acids, pKa afterpH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What adjuvant medication prolongs the duration of local anesthetics?

A
  • Dexmedetomidine
  • Magnesium
  • Clonidine
  • Ketamine
  • Dexamethasone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What will be the results of combining LA Chloroprocaine & Bupivacaine?

A
  • Produce a rapid onset
  • Tachyphylaxis (bupivacaine)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is added to 30 mL of LA to alkalinize the drug?

A

1 mL of 8.4% Sodium Bicarbonate

This will increase the non-ionized form of LA.
Make sure the mixture does not contain any precipitate.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

The toxic effects of combining LA are _______

A

Additive. (1+1 =2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Compare the onset of action between chloroprocaine and bupivacaine.

A

Chloroprocaine: Rapid
Bupivacaine: Slow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What vasoconstrictors are available to use with LA?

A

Epinephrine
Phenylephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Why is it important to use vasoconstrictors with LA?

A

The duration of action of a LA is proportional to the time the drug is in contact with nerve fibers. For this reason, epinephrine may be added to LA solutions to produce vasoconstriction, which limits systemic absorption and maintains the drug concentration in the vicinity of the nerve fibers to be anesthetized.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the results of using vasoconstrictors with LA?

A
  • Produce vasoconstriction
  • Increased neuronal uptake of LA
  • α-adrenergic effects may have some degree of analgesia
  • No effect on the onset rate of LA
  • Enhanced cardiac irritability with inhaled anesthetics
  • Systemic absorption → HTN (tachycardia)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is epinephrine 1:200,000 mean?

Convert that to mcg/mL.

A

1:200,000 means 1 gram of epinephrine is dissolved in 200,000 mL of solvent.

  • 1g/200,000 mL
  • 1000mg/200,000 mL
  • 1 mg/200 mL
  • 1000 mcg/200 mL
  • 10 mcg/2 mL
  • 5 mcg/mL
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Compute 1:500,000 to mcg/mL

A

2 mcg/mL

  • 1 g/500,000 mL
  • 1000 mg/500,000 mL
  • 1 mg /500 mL
  • 1000 mcg/500 mL
  • 10 mcg/5 mL
  • 2 mcg/mL

Shortcut: 1,000,000 divided by the solvent number. 1 million/500,000 = 2 mcg/mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How much epinephrine or phenylephrine is given with bupivacaine or lidocaine for a subarachnoid block (SAB)?

A
  • 0.2 mg Epi
  • 2 mg Phenylephrine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Compute 1:500,000 Epi to mcg/mL

A

1,000,000/ 500,000=2

2 mcg/mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Compute 1:10,000 Epi to mcg/mL

A

1,000,000/ 10,000 = 100

100 mcg/mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Compute 1:1000 Epi to mcg/mL

A

1,000,000/ 1000 = 1000

1000 mcg/mL

This is the epinephrine that we find in our crash carts.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

0.25% concentration is how many mg/mL

A

2.5 mg/mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

0.5% concentration is how many mg/mL

A

5 mg/mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

1% concentration is how many mg/mL?

A

10 mg/mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

2% concentration is how many mg/mL?

A

20 mg/mL

2% lidocaine is the most common concentration used in the OR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

4% concentration is how many mg/mL?

A

40 mg/mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Your surgeon injected 20 mLs of Bupivacaine 0.25% with 1:200,000 of Epi.

What are the total mgs for Bupivacaine and the total mcgs for Epinephrine?

A

Bupivacaine:
0.25% = 2.5 mgs/mL
2.5 mgs x 20 mLs = 50 mgs total

Epinephrine:
1:200,000 = 5 mcg/mL
5 mcg x 20 mLs = 100 mcg total

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Lidocaine Recommended Max Single Dose:

Lidocaine Recommended Max Single Dose with/Epi

Lidocaine Recommended Max Single Dose for Spinal

A

300 mg

500 mg w/ Epi

100 mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Mepivacaine Recommended Max Single Dose

Mepivacaine Recommended Max Single Dose with/Epi

Mepivacaine Recommended Max Single Dose for Spinal

A

400 mg

500 mg w/ Epi

100 mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Prilocaine Recommended Max Single Dose

A

600 mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Bupivacaine Recommended Max Single Dose

Bupivacaine Recommended Max Single Dose with/Epi

Bupivacaine Recommended Max Single Dose for Spinal

A

175 mg

225 mg w/ Epi

20 mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Clinical Scenario Question
112.5 mg of Bupivacaine with Epi and 250 mg of Lidocaine with Epi were given during surgery.

What are the percentages of each LA based on the recommended max single dose in mg?

A

Max single dose of Bupivacaine with Epi: 225 mg
112.5/225 = 50%

Max single dose of Lidocaine with Epi: 500 mg
250/500 = 50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Where are topical anesthetics applicable?

A

Applicable on the mucous membranes of the nose, mouth, tracheobronchial tree, esophagus, or GU tract.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Which anesthetic has localized vasoconstriction that will decrease blood loss and improve surgical visualization?

A

Cocaine (4-10%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Which anesthetic is great with surface anesthesia?

A

Lidocaine (2-4%)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Lidocaine inhalation does not alter airway resistance, but ______

A

vasodilation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What LA care not effective for topical anesthetic?

A

Procaine and Chloroprocaine

These drugs do not penetrate mucous membranes as effectively as cocaine or lidocaine.

36
Q

What is an LTA?

A
  • Lidocaine tracheal anesthesia
  • Localized tracheal anesthesia
37
Q

Eutectic Mixture of LA (EMLA) contains what LA?
Dose:
Onset:

A

Lidocaine 2.5% + Prilocaine 2.5% = 5% LA
Dose: 1 to 2 gms/ 10 cm2 area
Onset: 45 mins

38
Q

EMLA has to be applied for ______ hours before skin graft.

A

2 hours

39
Q

EMLA can be applied for 10 minutes before any of these procedures:

A

Cautery of genital warts
Venipuncture, lumbar puncture
Arterial cannulation (Nitroglycerine)
Myringotomy

40
Q

EMLA considerations

A
  • Caution with methemoglobinemia
  • Not recommended for skin wounds
  • contraindicated with amide allergies
41
Q

Other Topical Anesthesia Preparations besides EMLA

A
  • Amethocaine (EMLA-like)
  • Tetracaine 4% Gel
  • Lidocaine 7%
  • Tetracaine 7%
42
Q

What is considered local infiltration with LA?

A

Extravascular placement of LA (subcutaneous injection)

43
Q

What LAs are used on inguinal operative sites?

A
  • Lidocaine 1% or 2%
  • Ropivacaine 0.25%
  • Bupivacaine 0.25%
44
Q

How can you double the duration of LA for local infiltration?

A

Epinephrine 1:200,000

45
Q

What are the contraindications of using epinephrine on LA for local infiltrations?

A
  • Not intracutaneously or into tissues at end arteries
  • Fingers, toes, ears, nose, penis

Can cause necrosis.

46
Q

How is Peripheral Nerve Block achieved?

MOA?

A

Achieved by LA injection into tissues surrounding individual peripheral nerves or nerve plexuses.

MOA: diffusion from outer mantle to central core of nerve along a concentration gradient.

* Smallest sensory and ANS fibers first, then larger motor and proprioceptive axons.*

47
Q

Signs and Sx of Peripheral Nerve Block?

A

The proximal area (site of LA administration) is affected first and then distal.

48
Q

When the peripheral nerve block is wearing off, what comes back first? Proximal or Distal?

A

Proximal comes back first & then distal.

49
Q

Peripheral Nerve Block onset of action is dependent on _________.

Lidocaine OOA:
Bupivacaine OOA:

A

LA pK

Lidocaine OOA: 3 mins
Bupivacaine OOA: 15 mins

50
Q

Peripheral Nerve Block Duration depends on _____ of local anesthetic.

A

dose

51
Q

Continuous Infusion Blocks benefits.

A
  • Improved pain control
  • Less nausea
  • Greater satisfaction
  • Additives are used with continuous infusion blocks (ie: Ketolorac, Ketamine, Decadron)
52
Q

What is a Region Bier Block?

A

Bier Block IV injection of LA into an extremity isolated from the rest of the systemic circulation with a tourniquet.

Sensation and muscle tone dependent on tourniquet

53
Q

What LA is commonly used in Bier Block?

A

Lidocaine

54
Q

Bier Block Steps

A
  • IV start
  • Exsanguination
  • Double cuff
  • LA injection
  • Surgeon will perform procedure
  • IV D/C
55
Q

What is the sequence of blockades for a segmental block in Neuraxial Anesthesia?

A
  1. SNS (Myelinated preganglionic B fibers)
  2. Sensory (Myelinated A, B fibers, unmyelinated C fibers)
  3. Motor (Myelinated A-δ and unmyelinated C fibers)
56
Q

Clinical Scenario: Neuraxial blockade is the last reference with which assessment parameters

A. NIBP
B. Heart Rate
C. Cold Alcohol Pad
D. Leg Movement

A

D. Leg Movement

57
Q

How is a Spinal Anesthesia Block (SAB) produced?

A

Produced by direct injection of LA into subarachnoid

58
Q

What is used for confirmation of a Spinal Anesthesia Block (SAB)?

A

CSF

59
Q

What is the principal site of action for SAB?

A

Preganglionic fiber

60
Q

For SAB, the _______ effect is on the same level of denervation.

A

sensory

61
Q

For SAB, the _______ effect is 2 spinal segments cephalad of the sensory block.

For SAB, the _______ effect is 2 spinal segments below the sensory block.

A

SNS

Motor

62
Q

If the sensory block is at T5, where is the SNS block?

A

T3

This SNS block will trigger an asystole event.

63
Q

What dermatoses correspond with our cardiac accelerator?

A

T1 to T4

64
Q

Clinical Scenario Slide:
If the assessed sensory level after SAB is T6 ( Top of Xiphoid Process), what are the blocked SNS and motor levels?

A

SNS Block: T4
Motor Block: T8

65
Q

Most common LA used in SAB

A

Most common: Tetracaine, Lidocaine, Bupivacaine, Ropivacaine, and Levobupivacaine

66
Q

What factors affect SAB dosage?

A
  • Height of patient (volume of subarachnoid space)
  • Segmental level of anesthesia desired
  • Duration of anesthesia desired
67
Q

For SAB, _____ is more important than _______ of drug (%) or the volume (mLs) of the solution injection.

A

Dose; Concentration

68
Q

SAB Dose:
5 ft = _____mL of 0.75% Bupivacaine
+ ______ mL for every inch above…. 2 cc total ( 1½ hours to 2 hours)

A

1 mL
0.1 mL

For someone who is 5’5”, you will give 1.5 mL of bupivacaine for a SAB.

69
Q

For SAB, the _________ of LA is important in determining the spread of the drug.

A

specific gravity

70
Q

What can be added to LA so that its specific gravity can increase?

What can be added to LA so that its specific gravity can decrease?

A

Glucose added → hyperbaric solution.

Distilled water added → hypobaric solution

71
Q

Which side will you want to position a right-hip arthroplasty patient on if they receive a hyperbaric LA solution?

A

Right side lying, the hyperbaric solution will “sink.”

72
Q

Which side will you want to position a right-hip arthroplasty patient on if they receive a hypobaric LA solution?

A

Left side lying, the hypobaric solution will “float”.

73
Q

The most common LA used in Epidural Anesthesia.

A

Lidocaine

Good diffusion through tissue and safer

74
Q

What is the onset of epidural anesthesia?

A

Onset: 15 to 30 minutes

75
Q

Epi 1:200,000 with ___________ offers no advantage in an epidural block.

A

bupivacaine

76
Q

Can epidural anesthesia cross the placental barrier with OB and C-section patients?

A

Yes

77
Q

What is the difference between SAB and epidural blocks?

A

No differential zone of SNS, sensory, and motor blockade.

78
Q

What is considered an acceptable additive to both epidural and SAB to produce a synergistic effect?

A

Opioids

79
Q

What is Tumescent?

A

Subcutaneous infiltration of large volume (5L or more)

80
Q

What makes up the tumescent solution?

A
  • Diluted Lidocaine (0.05% to 0.1%)
  • Epinephrine 1:100,000
81
Q

What causes the tumescent effect?

A

The taunt stretching of overlying blanched skin d/t large volume → Tumescent Effect

Fat can be aspirated without blood loss and provide prolonged post-op analgesia.

82
Q

Where is tumescent usually administered?

A
  • Thigh
  • Abdomen
  • Hips
  • Buttocks
83
Q

When is the plasma peak for tumescent?

A

12 to 14 hours s/p injection.

84
Q

Regional Anesthesia Lidocaine with Epi Dose.

A

7 mg/kg

85
Q

Highly diluted Lidocaine with Epi Tumescent dose (mg/kg).

A

35 to 55 mg/kg

86
Q

What is the theory with the Tissue Buffering System?

A

1 gram of SQ can absorb up to 1 mg of Lidocaine

Anesthesia Pharm COPY of Andy's (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions