Local Anesthetics Flashcards
1
Q
How do NSAIDS negatively impact the kidney?
A
- Prostaglandins promote blood flow to glomeruli
- NSAID -> blocks prostaglandins -> vasoconstriction -> dec. renal perfusion
2
Q
What are the symptoms of Reye’s Syndrome?
A
- Swelling of liver and brain
- Diarrhea and rapid breathing (child <2)
- Vomiting, listlessness/drowsiness
- Confusion, weakness, seizures, loss of consciousness
3
Q
How does celecoxib interact with aspirin?
A
It does not alter anti-platelet effect of aspirin.
4
Q
What is the mechanism of local anesthetics?
A
-Inhibit sodium channels along the axons of neurons which prevents the propagation of action potentials down the neuron
5
Q
Both ionized and un-ionized forms of drug are. . .
A
. . .necessary for activity of drug
6
Q
What does the ionized form of the drug do?
A
Interacts with and blocks the Na+ channel.
7
Q
What does the un-ionized form of the drug do?
A
It can cross the plasma membrane and gain entry into the cell.
