Local Anaesthetic Flashcards
What is the structure of a LA molecule
Aromatic region (Hydrophobic)
Ester or Amide bond
Basic amine side chains (hydrophillic)
What is a LA molecule presented as and why
Hydrochloride to render the amine base more soluble making the injection less painful
Why is the LA molecule partly dissociated
Its active in its ionised form but can only cross the membrane in it unionised form
What is the composition of a LA preparation
LA base present as a hydrochloride 2-4% solution for dental use Reducing agent preservatives vasoconstrictor e.g. adrenaline
What are the 2 familys of LA
Esters and Amides
What are the most likely causes of an alergic reaction to LA
The rubber bung or preservatives in the LA
What are esters and amides broken down by
Esters- tissue esterases
Amides- liver amidases
What does a preperation of lignocaine consist of
2% lignocaine HCL or 2% lignocaine HCL + 1:80,000
What does a preperation of Prilocaine consist of
3% prilocaine HCL or 3% prilocaine + felypressin
What is the max dose of adrenaline
500ug
How much adrenaline does a cartridge contain
27.5ug
In the dental school what syringe is used
safety plus
What is the most fragile part of the needle
The hub
How do you asemble a syringe
1A- Colllect syringe handle and needle
1B- Collect selected LA cartridges (check batch no. and exp. date)
2A- Unpack everything
2B- record details for decontamination
3- Make up syringe handle, attach rubber bung so that the wider side faces towards the handle
4- Load cartridge of LA solution in the needle barrel, gold side in first
5- Connect syringe handle and LA needle with cartridge, should hear a click into place and then check for attachement
6- Prepare needle for use, pull back on safety sheath with needle away from you and sheath should click into place at connection between syringe and barrel. Make needle safe by re-sheathing with 1 click= safe but can be reused 2nd= needle locked
Why use LA
Undertake a range of dental procedures pain free