LO2 Flashcards
What 2 regulations come under the Health and Safety at Work Act (1974)?
- Ionising Radiation Regulations (1999)
- Ionising Radiation (Medical Exposure) Regulations (2000)
What is the Ionising Radiation Regulations (1999)?
Concerned with protection of staff.
The radiation protection supervisor (RPS) ensures that the practice complies with IRR 1999 and the local rules.
The radiation protection adviser (RPA) is an expert in radiation protection who can guide the practice RPS with regard to compliance and regulations.
What is the Ionising Radiation (Medical Exposure) Regulations (2000)?
Concerned with protection of patients.
It requires that all practitioners and operators who take dental radiographs and expose patients to radiation should be adequately trained.
What is excitation?
Raising of electron in atom to higher energy level without actual ejection of electron.
- Causes no biological change.
What is ionisation?
If radiation has enough energy, it can eject electrons.
- Cell’s molecular structure has changed – left with electron and positive ion.
What are the direct effects of ionisation?
X-ray photons interact with macromolecules (DNA, RNA, proteins, enzymes).
How do direct effects of ionisation occur?
▪ Radiation interacts directly with critical target.
▪ Deposits energy.
▪ Ionisation/excitation of atoms of critical target.
▪ Breaking of chemical bonds.
▪ Chain of events that lead to biological change in critical target.
▪ Damage to DNA = point mutation – effects include:
• Inability to pass on information.
• Abnormal replication.
• Cell death.
• Only temporary damage – DNA repaired successfully before further cell division.
What are the indirect effects of ionisation?
Photon disrupts water molecule into reactive free radicals that damage DNA.
How do the indirect effects of ionisation occur?
▪ Interacts with other atoms/molecules in cell (water) to produce free radicals.
▪ Free radicals = highly reactive and displace other atoms (breaks chemical bond) to become neutral.
• Damage DNA.
• OH + OH —> H2O2 (toxic to cell).
• H + O2 —> HO2 (biological damage to cell).
What are hereditary effects?
Effects in subsequent generations due to gonad irradiation – no evidence in human generations.
What are somatic effects?
Effects seen in person irradiated:
- Short-term or long-term after exposure.
Can be deterministic or stochastic.
What are deterministic effects?
Non-dental related.
Dose related – larger the dose, greater severity of effect. ▪ Effect doesn’t occur below threshold. ▪ Examples: • Cataract formation. • Loss of fertility. • Erythema of skin. • Radiation sickness.
What are stochastic effects?
Dental related.
Severity is not dose related.
▪ No known threshold.
▪ Probability of effect occurring increases with dose.
▪ Example: - cancer/tumour.
What is radio-sensitivity of cell affected by?
- Amount of energy transferred.
- Cell cycle.
- Presence/absence of oxygen.
- Type of cell.
How does the amount of energy transferred affect radio-sensitivity of cell?
o Linear Energy Transfer (energy deposited per unit of track length):
▪ Different particles deposit different amounts of energy (protons deposit more than alpha particles).
▪ Higher the LET, closer together reactions.
• Several OH molecules can be close and increase chance of H2O2 production.