LMR Flashcards
TSH Normal Range
-0.5 - 5 Mu/L
T4 Normal Range
0.8 - 2.8
Symptoms of hyperthyroidism can mimic symptoms of
Mania
TSH Down, T3 and T4 Up
Hyperthyroidism
Heat intolerance, agitation, anxiety, irritability, tachycardia, mood swings,
weight loss
Symptoms of hypothyroidism can mimic symptoms of
depression
TSH UP, T3 and T4 Down
Hypothyroidism
Cold intolerance, lethargy, weight gain, decreased libido
What drug - Can cause Spina Bifida (neural tube defect)
- Hepatotoxicity
Depakote - Divalproex Sodium
Patient taking depakote presents with signs of hepatotoxicity. List signs and symptoms
Abdominal pain in
the upper right portion of the abdomen, reddish brown urine, yellowing of the
skin and whites of the eye,fatigue
*Do a liver function test
AST normal range
5-40 U/l
ALT
5-35 U/l
The therapeutic range for valporic acid (total) is
50-125ug/mL.
The toxic level of valporic acid is
greater than 150 ug/uL
Signs of valporic acid toxicity
Disorientation, lethargy, respiratory depression,
nausea/vomiting
Intervention would you do for valporic acid toxicity?
DC med and check valporic acid levels, LFT and ammonia levels
***High yield
Herbal supplement used for anxiety, stress, insomnia
Kava Kava
Kava Kava can cause
Side Effects:
Hepatotoxicity - Can cause liver damage
Use a liver function test
What class of medications to avoid when taking kava kava?
Sedatives because it can cause excessive drowsiness
xanax
clonzapam
lorazepam
phenobarbital
zolpidem
What medication is associated with SJS (stevens-johnson syndrome)?
Lamotrigine (Lamictal)
S/S of Steven-johnson syndrome? signs and symptoms?
Fever, body aches, red rash, peeling skin, facial and tongue
swelling
What Mood stabilizer that causes the least weight gain?
Lamotrigine (Lamictal)
What Antipsychotics that can cause least weight gain?
Z.A.L
Ziprasidone - Geodon
Aripiprazole -Abilify (Least sedating)
Lurasidone - Latuda
Least sedating Antipsychotic?
Aripiprazole (Abilify)
For patients taking antipsychotics that can cause weight gain check routine labs like?
BMI, hip-to-waist ratio, glucose, and lipid panel
Interventions for Management of antipsychotic-induced weight gain (AIWG)?
1.Non pharmacologic interventions include Nutritional counseling and exercise
2.- Pharmacologic interventions consist of switching to another antipsychotic which
has less potential to gain weight (Ziprasidone, aripriprazole, lurasidone -ZAL-)
you need to eat 360 cals, preferably of
carbohydrates for which medications?
Ziprasidone (Geodon) and Lurasidone (Latuda)
Carbamazepine (Tegretol) can cause
- Agranulocytosis (decrease WBC) and Aplastic Anemia
Presents with pallor, fatigue, headache, fever, nosebleeds, bleeding gums,
skin rash and shortness of breath
Can cause SJS for ASIANS
Carbamazepine (Tegretol)
What to screen for before starting Carbamazepine (Tegretol) in asians?
SCREEN for allel HLAB-1502 before initiating
The HLA-B * 1502 is highly associated with the outcome of
carbamazapine-induced SJS
Clozaril can cause
agranulocytosis
Monitor patients taking carbamazepine and Clozaril for signs of
infection
Sudden fever, chills, sore throat, weakness
DC Clozaril and Carbamazepine at absolute neutrophil count (ANC)
less than 1000mm^3
whether patient is showing signs of infection or not
What is the baseline absolute neutrophil count (ANC) before initiating treatment with clozapine?
The baseline ANC must be at least 1500/μL for the general population, and at least 1000/μL for patients with documented Benign Ethnic Neutropenia (BEN)
What is the therapeutic range for absolute neutrophil count (ANC)?
2,500 to 6,000 per microliter
Lithium normal range
- 0.6 - 1.2 mEq/L
Lithium Toxicity can occur when levels reach what ?
1.5 meq/L or higher
What medication is gold standard for treating manic episodes?
Lithium
This is the only known antipsychotic medication that has been shown to reduce the risk of suicide in patients diagnosed with schizophrenia :
Clozapine (Clozaril)
Lithium can cause what birth defect?
Ebstein anomaly ( congenital heart defect)
inverted tricuspid valve
What labs to monitor for someone who is on Lithium?
Thyroid panel (TSH)
Serum creatinine (0..6- 1.2 mg/dl)
BUN (10-20mg/dl)
Urine analysis (check for proteins in urine. May indicate kidney disease
HCG for females of childbearing age 12yrs -51yrs
Side effects of Lithium
H.I.I.M
Hypothyroidism
inversions T wave
increased WBc’s (Leukocytosis)
maculopapular rash
Lithium is to ____
as Clozaril is to _____
Bipolar
Schizophrenia
Signs/ symptoms for lithium toxicity:
Severe nausea, vomiting, and diarrhea, confusion,
drowsiness, muscle weakness, heart palpitations, coarse hand tremors, and
unsteadiness while standing or walking
Intervention for Lithium toxicity
DC Lithium and check serum Lithium Levels
What can increase the serum levels of lithium?
Kidney disease
drugs that reduce renal clearance such as NSAIDS (Ibuprofen, Indocin
Thiazides (HCTZ)
ACE inhibitors (Prils)
dehydration and hyponatremia
**If patients go hiking and take extra water, that means that is good understanding
of lithium use
Neuroleptic malignant syndrome (NMS) is caused by
antipsychotics
Neuroleptic malignant syndrome (NMS) sign and symptoms :
Extreme muscular rigidity
Mutism
Muscles so rigid that the patient cannot talk
Hyperthermia
Tachycardia
Diaphoresis
Altered level of consciousness
Labs noted with Neuroleptic malignant syndrome (NMS)
Elevated CPK (Creatine phosphokinase) - muscle contraction/muscle destruction
Myoglobinuria - Resulting from the breakdown of muscle cells (rhabdomyolysis)
Elevated WBCs - Leukocytosis
Elevated LFTs - Liver function tests
Treatment of Neuroleptic malignant syndrome (NMS) :
DC the offending agent
Give bromocroptine (Parlodel) - Dopamine (D2) agonist
Dantrolene - Muscle relaxant (muscle rigidity)
Serotonin Syndrome is caused by
Antidepressants
These s/s are noted in what condition?
Hyperreflexia
Myclonic Jerks
agitation, anxiety, restlessness, disorientation, diaphoresis, hyperthermia, tachycardia, nausea, vomiting, tremor, muscle rigidity,
serotonin syndrome:
Treatment of serotonin syndrome:
DC Offending agent
Cyproheptadine
What herbal medication can cause serotonin syndrome
St johns wort
- Herbal medications can also cause Serotonin Syndrome
Can you mix SSRI/SNRI/TCA/MAOI
Do not place on multiple SSRIs or a mixture of the two
When switching from SSRI to MAOI/TCA/MAOI how long ?
14 days
One class to another wait the 14 days
When switching from Fluoxetine (Prozac) to MAOI/TCA/SNRI/SSRI how long?
- 5-6 weeks
This is because Fluoxetine (Prozac) has a long half-life
When switching from MAOI to Prozac; how long?
2 weeks
Triptans are used for:
Migraines - Sumatriptan (Imitrex)
SSRI/SNRI/TCA/MAOI
Mixture of the two can increase what?
serotonin levels
List some Norepinephrine and dopamine reuptake inhibitors (NDRIs):
Amineptine (Survector, Maneon, Directim)
Bupropion (Wellbutrin, Zyban)
Desoxypipradrol (2-DPMP)
Dexmethylphenidate (Focalin)
Difemetorex (Cleofil)
Diphenylprolinol (D2PM)
Ethylphenidate.
Fencamfamine (Glucoenergan, Reactivan)
What class of medications are safer for people who may overdose
SSRI
If a patient overdoses on an SSRI it has a lesser chance to cause an injury
If patient is depressed and has cancer
You can give them SSRIs as well
If a patient presents with low energy and fatigue. What medication can you give? Class?
Give them an NDRI - (Bupropion) Wellbutrin (can increase energy levels)
What two meds have Less potential for drug interactions
Citalopram (Celexa)
Escitalopram (Lexapro)
If patient has history of seizures or eating disorders what medication of avoid?
Bupropion (Wellbutrin)
Lower seizure threshold - Increasing seizure risk
If depressed and neuropathic pain give :
-SNRI
desvenlafaxine (Pristiq, Khedezla)
duloxetine (Cymbalta, Irenka)
levomilnacipran (Fetzima)
milnacipran (Savella)
venlafaxine (Effexor XR)
- TCA
amitriptyline (Elavil),
clomipramine (Anafranil),
doxepin (Sinequan),
imipramine (Tofranil),
trimipramine (Surmontil),
amoxapine (Amoxapine Tablets),
desipramine (Norpramin),
nortriptyline (Pamelor, Aventyl)
But remember about Safety for overdoses
-Even alpha 2 delta ligand medications
Gabapentin
Pregabalin
ALL ANTIDEPRESSANTS COULD ______________ , in
CHILDREN, ADOLESCENTS AND YOUNG ADULTS.
INCREASE THOUGHTS OF SELF-HARM
Always assess self-harm
Frequency and severeity
If patient is depressed, assess alcohol intake (may use to self-medicate)
Fluoxetine (Prozac). Take this medication what time of day?
Can cause insomnia, so take in the morning as opposed to the evening
Numerous conditions presents likely with homicidal ideation. Name some of those conditions:
Antisocial personality disorder
Schizoaffective,
BPD,
paranoid personality,
schizophrenia,
OC personality
D
Schizophrenia
Age of onset -
-18-25 males
-25-35 Females
In Schizophrenia what will you see on MRI/PET scans:
MRI/PET scan -
Enlarged ventricles,
- everything else is decreased in size
Do not give schizophrenic patients ________medications
Stimulant
potentiate dopamine release
- It will increase positive symptoms
- Antipsychotics lower ____.
(Neurotransmitter)
dopamine
Negative symptoms will get worse, but want to deal with positive symptoms first.
Might need social skills training
- Falls under tertiary levels of prevention
How do you perform a Mental status exam of a preeschooler 3-5 years old
Listen and observe cues.
Heavily dependent on clinical observation
Components
Clock drawing test
Serial 7s -
Learning items -Registration
Move from thought to thought that may or may not relate in
some way but never get to the point
Tangentiality
Provide unnecessary detail but eventually get to the point
Circumstantial
Refers to the themes that occupy the patient’s thoughts and perceptual
disturbances
Example - Suicidal ideations, homicidal ideations (SI or HI), plan, visual
hallucinations, auditory hallucinations
Thought content
Assess organization of patient’s thoughts and ideas
Normal: logical, linear, coherent and goal oriented
Abnormal: Associations are not clear, organized or coherent
Thought process
MIni mental status examination - MMSE (Folstein scale)
components :
CONCENTRATION /attention/calculation
I would like you to count backwards from 100 by sevens or do serial 7s
ORIENTATION
what is the year? season? date? day? month? where are we?
RECALL
REGISTRATION
–ability to learn new material- name 3 objects: one second to say each. Then ask the patient all 3 after you have said them. then repeat them until he/she learns all three.
FUND OF KNOWLEGDE
–who is the president/governor
What makes an antipsychotic atypical
-Serotonin - Receptor antagonism
5HT2A - Antagonism
typical antipsychotics has dopamine antagonism
First psychotic episode
Give what class of medication? Name a Few:
atypical antipsychotics, less likely to cause EPS due to the
serotonin receptor antagonism
Some atypical antipsychotics:
Seroquel
Geodon
risperidone
zyprexa
clozaril
First psychotic episode and want to stabilize them faster.
Give what class of medications?
What route?
Name a few:
Give them IM medications
Paliperidone (Invega)
Ziprasidone (Geodon)
Aripripazole (not written)
Hyperactivity of dopamine in the _______ pathway mediates positive
psychotic symptoms
Hallucinations, delusions, disorganized behavior
Mesolimbic pathway
Decreased dopamine in the ___________ to the dorsolateral
prefrontal cortex is postulated to be responsible for negative and depressed
symptoms of schizophrenia
Mesocortical pathway
The _________ pathway mediates motor movements
Nigrostriatal pathway
Dopamine blockade in this pathway can lead to increased acetylcholine levels
Nigrostriatal pathway
Dopamine has a reciprocal relationship with ?
Acetylcholine (ACh)
Bloackde of Dopamine (D2) receptors in this pathway can lead to (EPS)
Nigrostriatal pathway
What are some Extrapyramidal Symptoms?
Akathisia: Feeling restless like you can’t sit still. …
Dystonia: When your muscles contract involuntarily. …
Parkinsonism: Symptoms are similar to Parkinson’s disease. …
Tardive dyskinesia: Facial movements happen involuntarily.
Long-standing D2 blockade in the _________ can lead to tardive
dyskenisa
nigrostrital pathway
REGLAN can cause serious side effects, including:
Tardive dyskinesia (abnormal muscle movements).
Increase acetylcholine and decrease dopamine levels=
EPS
Decreased levels of dopamine receptors in this pathway can lead to increase
prolactin levels leading to hyperprolactinemia which clinically manifests as
amenorrhea, galactorhea (milk production from the breast unrelated to pregnancy or lactation) (Risperidone), sexual dysfunction and gynecomastia
Long term hyperprolactemia can be associated with osteroprosis
Tuberoinfiundibular pathway
Prolactin levels
Men - Less than 20ng/ml
Women - Less than 25ng/ml
An atypical antipsychotic drug that is metabolized to a major
extent by the cytochrome P450 enzyme CYP1A2
Clozapine
Can decrease the serum level of other drugs that are
substrates of that enzyme, thus possibly causing subtherapeutic drug levels
Enzyme Inducers
Cigarette smoking - VERY HIGH YIELD
Oral contraceptives
Schizophrenia - high rate of cigarette smoking
Olanzapine (Zyprexa) and cigarette smoking (inducer). How will you adjust dose?
If patient started smoking, you will need to increase the dosage
of Zyprexa
A few months later, they stopped smoking or started a smoking
cessation program, you want to decrease the dosage of Zyprexa
Can increase the serum level of another drugs that are
substrates of that enzyme, thus possibly causing toxic levels
Enzyme inhibitors
IF they started an inhibitor, they will cause high serum levels of their
medication
Medications that cause mania:
S.A.I.D
Steroids
Antidepressants (in people with bipolar)
Isoniazid (INH)
Disulfram (Antabuse)
Medications that cause
depression:
S.A.B.B.I R.A.P
Steroids
Antineoplastic drugs
Beta blockers - lols
Benzodiazepines
Interferon
Retroviral drugs
Accutane (Isotretinoin)
Progesterone
Steroids can cause
psychosis
If you are treating a patient with psychosis, and they are on abilify, and on
flonase/prednisone, it is because of the steroid component of their medicaiton, and
it is exacerbating their psychotic symptoms. You want to increase the dosage of
their antipsychotics.
Neurotransmitters for ADDICTION
Dopamine and GABA
These meds Can also cause delayed gastric emptying
Ranitidine, famotidine, omeprazole
Antacids
PPI - Protonix, Omeprazole
- Can decrease absorptions of psychotropic medications.
How many hours apart to take medications?
Take medications two hours apart to avoid delayed absorption
When giving older adults SSRI’s monitor for:
Increased anxiety
Medications can cause paradoxical effect. What is the meaning of paradoxical effect?
if patient is very anxious and agitated,
and you gave a benzodiazepine to help with anxiety and agitated, it is causing them
to be more anxious and agitated
- It is the opposite of what it was meant to treat
- If insomnia and gave them trazodone, it is causing them to stay awake all night
- Avoid the medication in the future
Apoptosis
Neuronal loss / Cell death
Bipolar disorder
What does D.I.G.F.A.S.T acronym mean?
Distractability
impulsivity/Irresponsibility?Indescretion (Lack of good judgement)
grandiosity (- Patient has self-exaggerated esteem, heightened esteem)
flight of ideas
activities
sleep
talkativeness
Bipolar disorder is very inheritable
If they gave you different risk factors, the greatest risk factor is family
history, through generations
Age at which bipolar disorder is most likely due to a medical condition is
45
years and above
First time presenting with manic or hypomanic episode it is most likely
due to:
a medical condition such as stroke
Borderline Personality Disorder:
What are some behaviors?
Treatment? Who developed treatment?
Goals of this therapy?
Presents with self-harming behavior
Recurrent suicidal behaviors
Treatment?
Therapy is mainstay - Dialectical Behavioral Therapy (DBT)
Goal: Decrease thoughts of self-harm
Developed by: Marsha Linehan
Patient with Borderline personality disorder is presenting with depressed mood, emotional lability, you can give
them
DEPAKOTE
Is a mental condition in which a person has blindness,
mutism, paralysis, or paresthesia (glove stocking syndrome), other nervous
system (neurologic symptom symptoms that cannot be explained by medical
evaluation
Conversion Disorder
Glove stocking, means
wearing gloves because they are cold
Symptoms usually begin suddenly after a stressful evaluation
Is an emotional or behavioral reaction
to a stressful event or change in a person’s life. The reaction is considered an
unhealthy or excessive response to the event or change within 3 months of it
happening.
Adjustment disorder
Examples: Stressful events or changes in life of your child or adolescents may be a family
move, the parents’ divorce or separation, the loss of a pet, or birth of a sibling
A sudden illness or restriction to your child’s life due to the chronic illness may
also result in adjustment response
Adjustment disorder with depressed mood: Presents with
feelings of
sadness, decreased interest, sleep, disturbance, appetite changes.
IF you can identify the stressor it is Adjustment disorder
Adjustment disorder with anxiety: Presents with symptoms of
feeling restless,
nervousness, lack of concentration
Adjustment disorder with disturbance of conduct:
A child may violate other
people’s rights or violate social norms and rules. Examples include not going to
school, destroying property, driving recklessly, or fighting
Adjustment disorder with mixed disturbance of emotions and conduct:
For example, child may
present with truancy, peer confict, verbal altercations, insomnia, and frequent
crying
It is an enduring pattern of angry or irritable mood and argumentative, defiant, or
vindictive behavior lasting at least 6 months with at least 4 of the associated
symptoms
-Loses temper
-touchy or easily annoyed
-angry or resentful
-argues with authority
-actively defies or refuses to -comply with requests or rules -from authority
-figures
-blames others
-Delibrately annoys others
-spiteful or vindicful
Oppositional defiant disorder
Treatment of Oppositional defiant disorder
Non-pharmacological
-Therapy is mainstay
-Family Therapy, with emphasis on child management skills; teaching
parents about positive reinforcement and boundary settings
-Child and parent problem-solving skills training
A repetitive and persistent pattern of behavior in which the rights of others or societal norms or rules are violated.
AGGRESION toward people or animals-bullies, threatens, intimidates ,initiates physical fights, uses a weapon to cause physical harm to others, physical cruel to people or animals, stealing while confronting a victim, forced sexual activity on someone.
LACK OF REMORSE
DESTRUCTION OF PROPERTY
deceit or theft
what disorder does this describe?
Conduct disorder
Treatment for conduct disorder
target mood and aggression
aggression and agitation treated with antipsychotics, mood stablizers, SSRI, and alpha agonist (clonidine and Guanfacine)
If you feel like the child needs to go to Juvenile Prison, it is most likely to be:
conduct disorder
At least two motor tics and one vocal tic for at least a year, does not have be at the
same time
Tics are not caused using a substance or medical conditions
Note - Children’s motor tics are fairly common and can be temporary
Wax and Wane in frequency but have occurred for more than 1 year
Tics started to appear before the age of 18
Tourette Syndrome (TS)
Primary Neurotransmitter involved in Tourette Syndrome (TS)
DNS
- Dopamine, norepinephrine (Noradrenaline), Serotonin
Hyperactivity of dopmainergic systems in the brain can cause Tourettes
Pharmacological management of Tourette Syndrome (TS)
Atypical antipsychotic
FDA: Haldol, Pimozide, Aripripazole
Medications such as clonidine (catapres, Kapvay) and Guanfacine (Intuniv)
can help control behavioral symptoms such as impulse control problems
and rage attacks
Is a psychiatric dx that may occur in patients within 4
weeks (4 weeks or less) of a traumatic event. Features include anxiety,
insomnia, poor concentration, intense fear, or helplessness, reexperiencing the
event and avoidance behaviors.
Acute stress disorder
Ex. Inpatient, patient becomes aggressive towards you and you dont want
to go back to work (anxiety, nightmares) if these symptoms last less than
a month, use acute distress disorder
If more than 4 weeks look at PTSD
Hallmark Symptoms
Intrusive re-experiencing of an extremely traumatic event
Increased arousal (Hyperarousal)
Avoidance of stimuli associated with the trauma
PTSD
Treatment for PTSD
SSRI, TCA
Prazosin for nightmares
Nonpharmacological treatment for PTSD
Nonpharmacological
EMDR/CBT
Phases of EMDR
Phases of EMDR
Desensiitization phase
Installation phase
Body Scan
The client visualizes the trauma, verbalizes the negative thoughts or
maladaptive beliefs, and remains attentive to physical sensations. This process
occurs for a limited time while the client maintains rhythmic eye movements. He
or she is then instructed to block out negative thoughts; to breathe deeply; and
then to verbalize what he or she is thinking, feeling or imaging.
What phase of EMDR?
Desensiitization phase of EMDR
The client installs and increases the strength of the positive thought that he
or she has declared as a replacement of the original negative thought.
What phase of EMDR?
Installation phase of EMDR
The client visualizes the trauma along with the positive thought and then
scans his or her body mentally to identify any tension within
What phase of EMDR?
Body Scan of EMDR
What part of the brain is associated with ADHD?
Frontal cortex
Basal Ganglia
Abnormalities of reticular activating system
Can lead to ADHD Symptoms
Abnormalities in the prefrontal cortex - inattentive type
Assess ______ History before placing patient on stimulants
cardiac
For parents who don’t want to start their child on stimulants for ADHD. You can offer non-stimulant such as :
Clonidine and Guanfacine - both FDA approved for children that 6-17 years old
Atomoxetine - Straterra - 6 years old and above, that have ADHD
Encourage the parent to start the patient on non-stimulant medication
Doing multiple dosing or placing them on extended release
Neurotransmitters involved in ADHD
DNS-Dopamine, norepinephrine (Noradrenaline), Serotonin
Neurotransmitters involved in OCD
Serotonin and Norepinephrine
Presence of anxiety-provoking obsessions (Recurrent and persistent
thoughts, impulses or images) or compulsions (for example tics) that function
to reduce the person’s subjective anxiety level
OCD
Pediatric Autoimmune Neuropsychatric Disorders Associated with
Streptococcal Infections (PANDAS) should be considered in all children with
sudden onset of
OCD Symptoms
If a child has strep infection, monitor for
OCD
Difference between OCD and Tourettes
OCD: INTRUSIVE THOUGHTS AND TICS
Tourettes: TICS ONLY
Someone deceives others by appearing sick, by purposely getting sick or by self-injury.
Usually presents with physical or mental symptoms that
induced for example drinking contaminating urine samples, taking
hallucinogens, injecting fecal material to produces abscesses, and similar
behavior.
Factitious disorder
1) It is the product of a severely dysfunctional early relationship between the
principal care giver and the child.
2) When the caregivers consistently disregard
the child’s physical or emotional needs, the child fails to develop a secure and
stable attachment with them.
3)The failure causes a severe disturbance of the
child’s ability to relate to others, manifested in a variety of behavioral and
interpersonal problems. Some children are fearful, inhibited, withdrawn,
apathetic, shows no emotion towards caregivers, others are aggressive,
disruptive and disorganized.
Abuse or Foster Care
What disorder is described above?
Reactive attachment disorder
Excessive worry, apprehension, or anxiety about events or activities occurs
more days than not for a period of at least 6 months.
GAD
Is an abrupt surge of intense fear or discomfort that reaches a peak within minutes, and during which time a variety of psychological and physical symptoms occur. These symptoms include rapid hear rate, sweating, shaking, shortness of breath, hot flashes an lightheadedness as well as a sense of IMPENDING DOOM, chills, nausea, abd pain chest pain, headache, numbness or tingling.
Panic Attack
Treatment of panic attacks
1) betablockers
2)Propranolol - Can cause bronchspasms, so you cannot give with albuterol
(bronchodilator)
3)Benzodiazepines - Habit forming, CNS depressant, if had to choose
between the two go with beta blockers
How do you treat Performance Anxiety
Acute condition. Give beta blocker & benzos
For Maintenance/long term give SSRI
Is a diagnosis given to people who experience recurrent
UNEXPECTED panic attacks - that is, the attack seems to appear out of nowhere.
The term recurrent refers to the fact that the individual has had more than one
unexpected panic attack
Panic Disorder
Childhood depressive disorder that is diagnosed in children older than age
6 but younger than age 18
Sad, always mad, etc
Frequent intense temper outburst (Hallmark sign)
Severe irritability
Anger
Dysruptive mood dysregulation Disorder (DMDD)