Liver Pathology Flashcards
Demographic of liver disease?
1.9% of all deaths due to liver disease
Eight leading cause of death
7.2/100.000/year chronic liver disease
57% Hepatitis C
24% Alcohol related
9% Non-alcoholic fatty liver
4% Hepatitis B
Indications and purpose of a liver biopsy?
Indications:
Acute and chronic liver dysfunction
Hepatomegaly
Space occupying lesions
Purpose
Cause
Severity (stage of progression)
Liver biopsy methods?
Open (per-operative)
Laparoscopic
Trans-jugular
Fine needle aspiration cytology
Per-cutaneous
blind
targeted
Diagnosis of liver disease?
Functional abnormalities:
Metabolism
Protein
Carbohydrate
Lipid
Bile acid
Bilirubin
Hormone and drug
Removal of microbes/toxins
Exctretion
Immunological function
Pathological manifestations:
Limited number of pathological response patterns to injury
Manifestation of liver disease?
Intracellular accumulation
Fatty change (steatosis)
Iron
Copper / Copper assoc. protein
Storage disease
Liver cell necrosis
Liver cell apoptosis
Inflammation
Cholestasis
Fibrosis
Pathogenesis of liver regen and damage?
Aetiology of acute liver diease?
ACUTE
Infective Hepatitis
Autoimmune
Toxic
Vascular Damage
Biliary Obstruction
gall stones
tumours
Metabolic
Aetiology of chronic liver injury?
CHRONIC
Infective Hepatitis
Autoimmune
Toxic
Vascular Damage
Biliary Disease
primary biliary cirrhosis
sclerosing cholangitis
graft vs host disease
transplant rejection
Metabolic
Causes of acute hepatitis?
Hepatitis viruses
EB Virus, CMV
Leptospirosis
Tell me about the hep viruses?
Tell me about he hep viruses and IG response in acute liver injury?
Tell me about hep and IG response in chronic viral injury?
Visual diff in acute and chronic hepititis?
Hep B stats?
Hep C stats?