Liver/Pancreas

Question 1

What pattern of damage is this?

What types of conditions cause it?

Answer 1

Random Multifocal distribution

Something blood borne (bacteria/viruses)

metastasis of tumors/neoplasia

Question 2

What pattern is this?

What might cause it?

Answer 2

Centrilobular damage

processes that impair blood flow

• severe anemia
• some toxins (CCl4 is a classic cause)

Question 3

What pattern is this?

What might cause it?

Answer 3

Midzonal

very rare damage, iron toxicity?

**glycogen accumulation will present in this pattern, but it’s typically not damaging

Question 4

What pattern is this?

What might cause it?

Answer 4

Periportal Distribution

• some ascending infections from the portal tract (GI infections)
• specific toxins

Question 5

What pattern is this?

What might cause it?

Answer 5

“Massive” hepatocellular damage

(damage to the entire lobule)

• specific toxins (blue green algae toxicity (k9), Tyler’s disease (horses))

Question 6

What is this liver structure?

What are the three circled areas?

Answer 6

portal triad

• bile ductule
• arteriole
• venule

Question 7

What is this image of?

Answer 7

icterus due to liver failure

Question 8

What symptom of liver failure is shown here?

Answer 8

hydrothorax

occurs in liver disease because you don’t have enough oncotic pressure to keep the fluid in the vessels

Question 9

What is this? Why does this indicate liver damage?

Answer 9

Photosensitization

Especially in ruminants, the liver inactivates chlorophyll so that it is no longer photoactive. Activated chlorophyll produces free radicals when exposed to UV light, which damages the skin

Question 10

What condition is shown here?

Answer 10

Acholic feces

All of the green is huge amounts of bile backed up into the liver from severe cholestasis

the feces is white due to lack of bile breakdown in the colon