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GI II > Liver Metabolism I > Flashcards

Liver Metabolism I Flashcards

1
Q

What is the rate limiting step of the classical/neutral pathway for bile acid synthesis?

A

7-hydroxylation

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2
Q

What enzyme catalyzes 7-hydroxylation in the classical/neutral pathway?

A

CYP7A1 (7-alphahydroxylase)

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3
Q

What catalyzes 27 hydroxylation in the alternate/acidic pathway?

A

CYP27A1 (sterol 27-hydroxylase)

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4
Q

What catalyzes 7-hydroxylation in the alternate/acidic pathway?

A

CYP7B1 and CYP39A1.

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5
Q

What is the CYP enzyme activated by ethanol? (and involved in NAPQI formation)

A

CYP2E1 (this is supposed to be in liver metabolism II, but whatever).

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GI II (7 decks)

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