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Liver function tests Flashcards

1
Q

is albumin a functional liver enzyme

A

yes

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2
Q

is prothrombin a functional liver enzyme

A

yes

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3
Q

is bilirubin a functional liver enzyme

A

yes

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4
Q

is ALT a functional liver enzyme

A

no

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5
Q

is ALP a functional liver enzyme

A

no

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6
Q

is GGT a functional liver enzyme

A

no

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7
Q

what are the three main patterns in interpretation LFT deranged tests

A

hepatitis
cholestasis
mixed

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8
Q

what is the normal upper limit of ALT

A

55

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9
Q

What does elevated ALT suggest

A

injury to hepatocytes

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10
Q

what does hepatitis have a predominant rise in

A

transaminases (ALT, AST)

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11
Q

which gender is autoimmune hepatitis more common in

A

females

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12
Q

symptoms of autoimmune hepatitis

A

often asymptomatic
tired
weight loss
RUQ discomfort

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13
Q

what is elevated in Autoimmune hepatitis

A

ALT
IgG
Plasma cells

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14
Q

what do you use to treat autoimmune hepatitis during the acute phase (elevated ALT phase)

A

steroids e.g prednisolone

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15
Q

what do you use to treat autoimmune hepatitis during the longer phase

A

steroid sparing agent

azathioprine,6-Mp

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16
Q

What should you watch out for the development of in people with autoimmune hepatitis

A

fibrosis/ cirrhosis

17
Q

what is the most common type of hepatitis in Scotland

A

Hepatitis C

18
Q

who is at risk of hepatitis C

A

illicit drug misuse via IV route
blood products
ethnicity (Pakistani, Indian)

19
Q

what is the most common causes of hepatitis C

A

non alcoholic fatty liver disease

20
Q

what does hepatitis c cause a rise in

A

ALT levels

21
Q

what is hepatitis C associated with

A

metabolic syndrome

22
Q

treatment of hepatitis C

A

liftestyle intervention

minimum 7% body weight loss maintained over a year

23
Q

what does cholestasis mean

A

bile not moving

24
Q

what is elevated in cholestasis

A

ALP
Bili
GGT

25
Q

is ALT elevated in cholestaiss

A

can be mild elevated or normal

26
Q

what is the upper limit normal for Bili

27
Q

is ALP higher or lower in teenagers

A

higher due to bone development

28
Q

conditions that can causes cholestasis

A

gallstones
obstructing tumours
primary bile cirrhosis
primary sclerosis cholantitis

29
Q

what type of condition is primary bile cirrhosis

A

autoimmune

30
Q

who is PBC most common in

A

women ages 50-65

31
Q

PBC symptoms

A

fatigue
itch
jaundice
high cholesterol

32
Q

what is used to make bile less sticky in PBC

A

ursodeooxycholic

33
Q

reasons for a mixture of hepatitis and cholestasis

A

alcohol
drug induced injured liver
obstructing/ parenchymal tumours

GI liver function tests (1 decks)

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