Liver function tests Flashcards
is albumin a functional liver enzyme
yes
is prothrombin a functional liver enzyme
yes
is bilirubin a functional liver enzyme
yes
is ALT a functional liver enzyme
no
is ALP a functional liver enzyme
no
is GGT a functional liver enzyme
no
what are the three main patterns in interpretation LFT deranged tests
hepatitis
cholestasis
mixed
what is the normal upper limit of ALT
55
What does elevated ALT suggest
injury to hepatocytes
what does hepatitis have a predominant rise in
transaminases (ALT, AST)
which gender is autoimmune hepatitis more common in
females
symptoms of autoimmune hepatitis
often asymptomatic
tired
weight loss
RUQ discomfort
what is elevated in Autoimmune hepatitis
ALT
IgG
Plasma cells
what do you use to treat autoimmune hepatitis during the acute phase (elevated ALT phase)
steroids e.g prednisolone
what do you use to treat autoimmune hepatitis during the longer phase
steroid sparing agent
azathioprine,6-Mp
What should you watch out for the development of in people with autoimmune hepatitis
fibrosis/ cirrhosis
what is the most common type of hepatitis in Scotland
Hepatitis C
who is at risk of hepatitis C
illicit drug misuse via IV route
blood products
ethnicity (Pakistani, Indian)
what is the most common causes of hepatitis C
non alcoholic fatty liver disease
what does hepatitis c cause a rise in
ALT levels
what is hepatitis C associated with
metabolic syndrome
treatment of hepatitis C
liftestyle intervention
minimum 7% body weight loss maintained over a year
what does cholestasis mean
bile not moving
what is elevated in cholestasis
ALP
Bili
GGT
