Liver Function Tests Flashcards

1
Q

aminotransferases

A

1) Alanine aminotransferase (ALT)
2) Aspartate aminotransferase (AST)

both are elevated with hepatocyte injury

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2
Q

alkaline phosphotase

A

elevation indicates cholestasis (gallstones)

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3
Q

bilirubin

A

measures liver’s ability to detoxify metabolites and transport organic anions into bile
**when elevated can show impaired hepatic function.. determine whether it is mostly direct (conjugated) or indirect (unconjugated)

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4
Q

albumin

A

severe impairment in liver function reduces albumin (liver failure)

  • synthesized exclusively in the liver
  • hypoalbuminemia can occur with heart failure, malnutrition, and nephrotic syndromes too
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5
Q

prothrombin time

A

reflects the degree of liver failure

  • PT increases as the ability of the liver to synthesize clotting factors diminishes
  • correlates with severity of liver failure/hepatic dysfunction
  • AKA INR
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