Liver Flashcards
Why do we want to be careful with our opioid use in liver disease?
Risk for sphincter of Oddi spasm
Sphincter of Oddi spasm will happen in about __% of the population given opioids
3%
Is there any way to predict who will experience sphincter of Oddi spasm?
No.
How can we antagonize sphincter od Oddi spasm?
Glucagon (.3mg up to 3 times) - can cause hyperglycemia and vomiting NTG (10mcg/min) - good for those with heart failure Naloxone (Narcan) - Will reverse the analgesic effect and have a bunch of other SE Nubain
What is the incidence for halothan hepatitis?
1: 10,000-30,000
This IA doesn’t cause hepatitis and why?
Sevoflurane does not undergo metabolism to trifluoroacetylated metabolites and is therefore not expected to produce immune-mediated hepatotoxicity or to cause cross-sensitivity
Reasons for post-op hepatic dysfunction
o Multi-factorial
o Review all drugs administered
o Check for sepsis
o Evaluate the possibility of increased bilirubin
o Rule out occult hematomas → hyperbilirubinemia
o Review peri-operative record for hypotension, hypoventilation, hypoxemia, hypercarbia, and hypovolemia***
This is the most common blood borne pathogen in the US
Hep C
HEV is transmitted via this route and in locations
Transmitted enterically
Asia, Africa, and Central America
In viral hepatitis, AST/ALT values may be as high as
400-4,000
Treatment for Hepatitis B
Interferon, Lamivudine, Adefovir (these will affect what drugs we use
Treatment for Hepatitis C
Interferon and Ribavirin
Treatment for autoimmune hepatitis
Corticosteroids and AZT
Cirrhosis is most commonly due to
HepC and ETOH abuse
The hepatic artery and portal vein both supply 50% of O2 each, but ____ provides 75% of total blood flow and ____ provides 25% of total blood flow
Hepatic artery = 25%
Portal vein = 75%
The liver is the site of synthesis of all clotting factors except
vWF
Patients with cirrhosis will have hyperdynamic circulation. What does this mean?
High CO
Low SVR
S/S of cirrhosis
o Fatigue /malaise o Anorexia/ weakness o Nausea/ vomiting o Abdominal pain o Jaundice /spider nevi o Hypoalbuminemia o Coagulation disorders o Endocrine disorders o Hepatic encephalopathy o Gastroesophageal variceal o Hepatomegaly /ascites
Many alcoholics can get cardiomyopathy. How does this affect your anesthetic?
Don’t give anything that depressed the myocardium
How do the majority of cirrhosis patients die during abdominal surgery?
60% die from bleeding