Live/Bile SSL Lecture

Question 0

What do portal areas (triads) at each corner contain?

What lies in the middle?

Answer 0

hepatic artery
portal vein
bile duct
A central vein lies in the middle.

Question 1

What is a classic lobule?

Answer 1

the hexagonal arrangement of hepatocytes

Question 2

What is the most functional unit of the liver?

Answer 2

Liver acinus

Question 3

What is crucial for hepatocyte efficiency?

Answer 3

proximity to blood supply

Question 4

What are the 3 concentric zones that incorporate portions of adjacent lobules? What do they do?

Answer 4

Zone 1
Zone 2
Zone 3

Question 5

Where is the space of disse located?

What flow there and where does it come from?

Answer 5

between hepatocytes and endothelium of sinusoids?
plasma (protein rich fluid) flows from the sinusoids into the space of disse. Lymph sent via channels to inferior vena cava or thoracic duct

Question 6

What is portal hypertension?

What might happen as a result?

Answer 6

It is back pressure of blood into portal circulation due to flow obstruction.
Result: Varicosities in portal-caval anastomoses (hemerroids, caput medusaed and esophageal varices might result)

Question 7

Describe Ascites.

Answer 7

• Portal hypertension increases lymph flow into the space of Disse
• excess lymph seeps through the visceral layer of peritoneum and creates fluid build-up in the peritoneal cavity. (this is ascites)
• a drop in blood volume stimulates renal salt and water retention until blood volume is restored