Lithium

Question 1

Lithium - indications

Answer 1

1) manic episodes (bipolar disorder) - usually second-line if antipsychotics do not work (given in addition to antipsychotics)
2) hypo-mania
3) regular periods of depression, where treatment with other medicines has not worked

Question 2

Lithium - side effects

Answer 2

1. nausea
2. vomiting
3. diarrhoea
4. a dry mouth
5. a metallic taste in the mouth.

severe: Lithium toxicity :
Increasing diarrhoea, vomiting, anorexia, muscle weakness, lethargy, dizziness, ataxia, lack of coordination, tinnitus, blurred vision, coarse tremor of the extremities and lower jaw

Question 3

Lithium - contraindications

Answer 3

1. Cardiac disorders associated with Rhythm
2. Renal impairment
3. Addison’s disease
4. untreated / untreatable Hypothyroidism
5. Breastfeeding

Question 4

Interactions

Answer 4

DO NOT HAVE WITH:

1. Thiazide diuretics (reduce clearance of lithium)
2. NSAIDs : increase serum lithium levels
3. ACEi - reduce clearance of lithium

Question 5

advice

Answer 5

if dose is missed do not double dose in 1 day.