Lists - PCN, Sulfa, Cephs 02

Question 1

Imipenem is cleaved by

Answer 1

Metallo-beta-lactamases

KPC

Question 2

Most susceptible cephalosporin to ESBLs

Answer 2

Ceftazadime

Question 3

No cephalosporin is effective against

Answer 3

Enterococcus

Listeria

C.difficile

KPC producing enterobacteriacea

Question 4

Places where penicillins do not distribute to

Answer 4

Eye

Brain/CSF

Prostate

Bone

Joints

Question 5

Worse for seizures

Answer 5

Imipenem

Pen G

Question 6

Elimination: All are renal except (biliary):

So no dose adjustment in renal failure

Answer 6

Nafcillin, Oxacillin, Dicloxacillin (NOD)

Ceftriaxone

Anti-pseudomonal penicillins

Question 7

Vancomycin side effects

Answer 7

RON:
Red man syndrome

Ototoxicity (permanent)

Nephrotoxicity (reversible)

Question 8

Only 1st or 2nd gen cephalosporin that crosses BBB

Answer 8

Cefuroxime axetil

Question 9

Bacterial Cell Wall Synthesis Inhibitors

Stage 1

Answer 9

D-Cycloserine

Fosfomycin

Question 10

Bacterial Cell Wall Synthesis Inhibitors

Stage 2

Answer 10

Vancomycin (sits on top of D-Ala-D-Ala so brick does not fit)

Telavancin

Teichoplanin

Dalbavancin

Oritavancin

Bacitracin (inhibits transporter of phosphate group)

Question 11

Bacterial Cell Wall Synthesis Inhibitors

Stage 3

Answer 11

Beta Lactam antibiotics