List I - Core Conditions Flashcards
How is grief commonly organised into stages?
- Denial
- This may include a feeling of numbness and also pseudohallucinations of the deceased, both auditory and visual
- Occasionally people may focus on physical objects that remind them of their loved one or even prepare meals for them
- Anger
- Commonly directed against other family members and medical professionals
- Bargaining
- Depression
- Acceptance
People may not go through all 5 stages
Who is more at risk of atypical grief?
- Women and if the death is sudden and unexpected
* Problematic relationship before death or if the patient has not had much social support
What are the features of atypical grief?
- Delayed grief - said to occur when more than 2 weeks passes before grieving begins
- Prolonged grief - difficult to define, normal grief reaction that may take up to and beyond 12 months
What is anxiety defined as?
- Excessive worry about a number of different events associated with heightened tension
What are the important alternative diagnoses of anxiety?
- Hyperthyroidism
- Cardiac disease
- Medication induced anxiety
Which medications can trigger anxiety?
- Salbutamol
- Theophylline
- Corticosteroids
- Anti-depressants
- Caffeine
What is the step wise approach to the management of anxiety according to NICE?
- Step 1: education about GAD + active monitoring
- Step 2: low intensity psychological interventions (individual non-facilitated self-help or individual guided self-help or psychoeducational groups)
- Step 3: high intensity psychological interventions (cognitive behavioural therapy or applied relaxation) or drug treatment. See drug treatment below for more information
- Step 4: highly specialist input e.g. Multi agency teams
What is the drug treatment approach to the treatment of anxiety?
- Sertraline should be considered the first-line SSRI
- Patients under the age of 30 years NICE recommend you warn patients of the increased risk of suicidal thinking and self-harm. Weekly follow-up is recommended for the first month
What is the step wise approach to the management of panic disorder according to NICE?
- Step 1: recognition and diagnosis
- Step 2: treatment in primary care - see below
- Step 3: review and consideration of alternative treatments
- Step 4: review and referral to specialist mental health services
- Step 5: care in specialist mental health services
What is the recommended treatment of panic disorder in primary care according to NICE?
- Either CBT or drug treatment
- SSRI’s are first line - if contraindicated or no response after 12 weeks then imipramine or clomipramine should be offered
What is the ICD10 definition of bipolar affective disorder?
- Two or more episodes in which a persons mood and activity levels are significantly disturbed
Consisting of on some occasions: - Elevation in mood and increased activity and energy levels (hypomania or mania)
- Lowering of mood and decreased activity and energy levels (depression)
Repeated episodes of hypomania or mania only are classified as bipolar
What is the ICD10 of hypomania?
- Persistent mild elevation of mood including:
- Increased energy and activity
- Marked feelings of well-being
- Feelings of physical and mental efficiency
- Increased sociability
- Talkativeness
- Over-familiarity
- Increased sexual energy
- Decreased need for sleep
- Irritability, conceit, boorish behaviour may take the place of the more usual euphoric sociability
- Disturbances of mood are not accompanied by hallucinations and delusions
- Symptoms not to the extent that they lead to severe disruption of work or result in social rejection
What is the ICD10 of manic episode?
- Elevated mood
- Increased energy
- Reduced concentration
- Reduced need for sleep
- Inflated self esteem grandiosity
- Reckless behaviour - overspending, promiscuity
- Increased libido
- Racing thoughts, pressured speech
- Irritability, aggression
- Psychomotor agitation
- Disinhibition
What is the ICD10 for mania with psychotic symptoms?
- In addition to the mania described:
- Grandiose delusions
- Hallucinations (usually voices speaking directly to the patient)
- Excitement or excessive motor activity can be so extreme that the patient is incomprehensible
What are the indications for prescribing lithium?
Indications
- Mania- treatment and prophylaxis
- Bipolar affective disorder
- Recurrent depression
- Aggressive or self mutilating behaviour
What are the kinetics (ADME) of lithium?
- Absorption is rapid
- Excretion is via the kidneys - clearance depends on renal function, fluid intake, Na intake
- Levels after last dose (0.4-1.0) therapeutic range but guided by clinical response
What are the baseline investigations for lithium before starting a patient on it?
- Physical examination and weight
- U&E’s, renal function, TFT’s, Ca
- ECG
- Pregnancy test - female
What are the monitoring requirements for lithium?
- Aim for the therapeutic window of 0.4-1.0
- Monitor levels every 3/12 when the patient is stable
- Renal, thyroid, Ca2+, weight and ECG
- Avoid drugs which reduce renal excretion such as ACEi, NSAID’s diuretics, thiazides, etc
What are the early side effects of lithium use?
- Dry mouth, metallic taste in mouth, fine tremor, fatigue, polyuria, polydipsia
What are the late side effects of lithium use?
- Diabetes insipidus, hypothyroidism, arrhythmias, ataxia, dysarthria, weight gain
What are the signs/causes of lithium toxicity?
- Drugs (NSAIDs, diuretics), renal failure, UTI, dehydration
- Levels - may occur if lithium >1.5 but treat the symptoms as well as the levels
- Symptoms
- Early - blurred vision, anorexia, nausea, vomiting, diarrhoea, coarse tremor, ataxia, dysarthria
- Late - confusion, renal failure, delirium, fits, coma, death
What is the management of lithium toxicity?
- Medical emergency - A to E
- Stop the lithium
- Give fluids
- Start diuresis / dialysis
- Treat the cause - e.g. stop nephrotoxic drugs
What is pseudodementia?
- Understood as a specific clinical entity, characterised by cognitive deficits, mimicking dementia occurring on a background of psychiatric disorders, especially depression
How can depression be differentiated from dementia?
Factors suggesting a diagnosis of depression over dementia:
- Short history, rapid onset
- Weight loss, sleep disturbance
- Patient worried about poor memory
- Reluctant to take tests, disappointed with results
- Mini-mental test score variable
- Global memory loss (dementia characteristically causes memory loss)