Lippincotts 2 - CNS Flashcards
what does the CNS consist of?
Brain and spinal cord
how much does the brain weigh at birth?
describe the growth in the first 3 years (weight)
how much does the adult brain weigh?
at birth the brain weighs 400g
during the first 3 years the weight of the bhrain triples
adult brain weighs 1400g, 2% body weight
from what does the adult nervous system originate during development?
when does development of the nervous system begin?
simple ectodermal tube. beginning the end of week 3 of gestation.
describe the development of the neural tube…
- ectodermal plate thickens to form neural plate
- neural plate fold around the midline groove
- broad rostral end, fold appear (pivot points)
- fusion begins on day 22
- cranial neuropore closes day 24
- caudal neuropore closes day 26
what are neural crest cells?
what do they differentiate into?
neural crest cell appear as the fusion of the neural tube occurs. cells from the crest dissociate and migrate away from the neural tube.
they differentiate into a variety of cell types, inc:
- adrenal medulla
- odentoblasts
- schwann cells
- sensory neurons in spinal ganglia
- pigment cells (melinocytes)
- endocardium cushion cells and spiral septum
- branchial pouches (bone/cartilage)
- arachnoid pia
developemtn of the brain: primary vesicles to secondary vesicles of neural tube…
the brain starts to develop in the 4th week of gestation. primary vesicles: (rostal to caudal) 1. prosencephalon (forebrain) 2. mesencephalon (midbrain) 3. rhombencephalon (hindbrain)
secondary vesicles:
1. prosencephalon »_space;> telencephalon
diencephalon
- mesencephalon »_space;> mesencephalon
- rhombencephalon»_space;> metencephalon
myelencephalon
what does the prosencephalon subdivide to form?
the prosencephalon is the forebrain. this primary vesicles divides into the telencephalon (cerebral hemispheres) and the diencephalon (thalamus, hypothalamus and subthalamus)
what is the mesencephalon?
the mesencephalon is a vesicle in the brain. it does not subdivide and forms the midbrain.
what does the rhombencephalon form?
the rhombencephalon is the forebrain. the rhombencephalon is a primary vesicle that subdivides into the rostral metencephalon (pons and cerebellum) and the caudal myelencephalon (medulla)
what are the lobes of the cerebral hemisphere?
the telencephalon grows to form a complex 3d structure. expands to form:
- frontal lobes, anterior
- parietal lobes, lateral and superior
- occipital lobes, posterior and inferior
- temporal lobes
expansion results in the cerebral hemisphers covering the diencephalon, midbraina and pons. (cerebellum is posterior, not covered)
what is grey matter?
grey matter is the accumulation of neuronal cell bodies
- in the brain, grey matter is found in the cortical layer and deep structures of the brain, also in brainstem (cranial nerve nuclei)
- in CNS collection of neuronal cell bodies are called nuclei
- in PNS collection of neruonal cell bodies are called gangia
- in the spinal cord grey matter is found centrally surrounded by white matter
what is white matter?
what are tracts?
white matter is the sum of all fibre tracts.
axons are mostly myelinated and therefore appear more white than grey matter.
a tract is a bundle of axons travelling from one area to another.
a tract in the PNS is called a nerve
what is the telencephalon?
the telecephalon is composed of a huge cerebrum, which is divided into cerebral hemispheres. they are covered by grey matter. deep to the grey matter are structures which include:
- basal ganglia - limbic system structures (hippocampus and amygdala)
what is the diencephalon?
the diencephalon is formed from the prosensephalon and forms the caudal end of the forebrain. it consists of the thalamus, hypothalamus and subthalamus
what are the four lobes of the cerebral hemispheres?
- frontal
- parietal
- occipital
- temporal
plus the limbic lobe…