Lippincott Chapter 24: Pituitary and Thyroid

Question 1

24.1 All of the following drugs may be beneficial in the
treatment of patients with acromegaly except:
A. Lanreotide.
B. Octreotide.
C. Pegvisomant.
D. Somatropin

Answer 1

Correct answer = D. Acromegaly is characterized by an
excess of GH. Somatropin is synthetic human GH, so
it would not be beneficial in this setting. Lanreotide and
octreotide are synthetic analogs of somatostatin, which
inhibits GH. Pegvisomant is an antagonist at GH receptors
and is used to treat acromegaly.

Question 2

24.2 A 40-year-old female is undergoing infertility treatments.
Which of the following drugs might be included in her
treatment regimen?
A. Cabergoline.
B. Follitropin.
C. Methimazole.
D. Vasopressin.

Answer 2

Correct answer = B. Follitropin is a recombinant version of
FSH that causes ovarian follicular growth and maturation.
Cabergoline is a dopamine agonist that is used for hyper-
prolactinemia. Methimazole is the treatment of choice for
hyperthyroidism. Vasopressin is an antidiuretic hormone.

Question 3

24.3 Which of the following is the treatment of choice for
hypothyroidism?
A. Iodide.
B. Levothyroxine.
C. Liothyronine.
D. Liotrix.
E. Propylthiouracil.

Answer 3

Correct answer = B. Levothyroxine is preferred due to its
long half-life and better tolerability. Liothyronine (T3
) and
liotrix (T3
/T4
) are not as well tolerated. Iodide and propyl-
thiouracil are used in the treatment of hyperthyroidism.

Question 4

24.4 All of the following agents are correctly paired with an
appropriate clinical use of the drug except:
A. Desmopressin—treatment of diabetes insipidus.
B. hCG—treatment of infertility.
C. Octreotide—treatment of bleeding esophageal
varices.
D. Oxytocin—induction of labor.
E. Goserelin—growth hormone deficiency.

Answer 4

Correct answer = E. Goserelin is a GnRH analog that may
be used for the treatment of prostate cancer or endometrio-
sis. The other choices are paired correctly with their respec-
tive clinical uses.