lipoprotein

Question 1

Where is the origin of Lp (a)?

A. Intermediate density lipoprotein
B. Intestine
C. Liver
D. VLDL

Answer 1

Ans. C

Question 2

Which among the following lipoprotein is the largest in terms of size (nm)

A. IDL
B. HDL
C. Lp (a)
D. VLDL

Answer 2

Ans: D. VLDL

Chylomicron is the largest plasma lipoprotein

Question 3

A human disease that is associated with excess Apo E?

A. Hyperchylomicronemia
B. Hyperlipolrotenemia type III
C. Hypertriglyceridemia
D. Hypobetalipoproteinemia

Answer 3

Answer:B

A- Apo C-II
C - Apo A-V and Apo C-III
D - Apo B100

Question 4

What is the smallest plasma lipoprotein?

A. HDL1
B. HDL2
C. HDL3
D. HDL4

Answer 4

Answer: HDL3

Smallest to Largest

HDL3 >HDL2>LDL>IDL>VLDL>chylomicron

Question 5

3 physiologically relevant receptors which iteract with HDL paticles

Answer 5

1. Scavenger receptor class B (SR-B1)
2. ATP-binding cassette transporter A1 (ABCA1)
3. ABCG1

Question 6

What gene is associated with hypercholesterolemia?

A. ABCA1
B. ABCG5
C. PCSK9
D. SMPD1

Answer 6

Ans: C. PCSK9

ABCA1 - Tangier Disease
ABCG5 and G8 - Sitosterolemia
SMPD1 - Nieman Pick types A and B

Question 7

Target receptor of cholesterol absorption inhibitor EZETIMIBE?

A. Niemann-Pick C1-like 1 (NPC1L1)
B. NPC1L2
C. NPC1L3
D. NPC1L4

Answer 7

Ans: A

Question 8

Major cholesterol transporter in humans

Answer 8

LDL