Lipids (Characteristics to Forms) Flashcards
What are the components that make up a lipid molecule (3 answers)
Carbon
Hydrogen
Oxygen
What transports lipids?
Lipoproteins
What enzyme cleaves fatty acids?
Pancreatic lipase
Triglycerides are converted into?
(2 answers)
Monoglycerides
Diglycerides
Cholesterol esters are transformed into?
Free cholesterol
Phospholipids are converted into?
Lysophospholipids
What does amphiphatic mean? (2 answers)
Containing a hydrophilic/polar end and a hydrophobic/nonpolar end
Amphiphatic lipids aggregate with ______________ and form ____________
Aggregate with bile acids
Form micelles
Micelles are absorbed into the blood through what organ?
Intestines
Micelles, when re-esterified, turn into what? (2 answers)
Triglycerides
Cholesteryl esters
What molecules make up triglycerides?
3 molecules of fatty acids
1 molecule of glycerol
Triglycerides are also known as?
Triacylglycerol
What characteristics of triglycerides make it an ideal main storage form of lipid?
Hydrophobic
Water insoluble
Most triglycerides from plant sources come in what form?
Unsaturated fatty acids
Exist as oils
Triglycerides from animal sources come in what form?
Saturated fatty acids
Solid (at room temperature)
Triglycerides are called as such due to having no charge
Neutral fats/lipids
Three roles of triglycerides
Energy source
Integral part of cell membrane
Insulation or shock absorber
Lipid that is not readily catabolized by most cells
Cholesterol
Four roles of cholesterol
Part of cell membrane
Promote fat absorption as detergents
Can be converted to steroid hormones
Can be transformed to vitamin D3 by sunlight exposure
What tissues can convert cholesterol to steroid hormones
Tissues from endocrine system
(e.g. adrenal gland, testis, ovary)
The two forms of cholesterol in the body
Free cholesterol
Cholesterol (Cholesteryl) Esters or Esterified
Approximately 60-70% of total cholesterol in the body
Cholesterol Esters
Composed of cholesterol ring and fatty acid
Cholesterol Esters
Approximately 30-40% of cholesterol in the body
Free Cholesterol
Unesterified cholesterol
Free Cholesterol
Composed of cholesterol ring only
Free cholesterol
No fatty acids attached
Free cholesterol
Composed of 2 fatty acid molecules, phospholipid head group, and a glycerol molecule
Phospholipids
What is a phospholipid composed of?
2 fatty acid molecules
Phospholipid head group
Glycerol molecule
70-75% of total phospholipid in the body
Phosphatidylcholine
18-20% of total phospholipids in the body
Sphingomyelin
3-6% of total phospholipids in the body
Phosphatidylserine
Phosphatidylethanolamine
4-9% of total phospholipids in the body
Lysophosphatidylcholine
Components of phospholipid head group
Choline
Inositol
Serine
Ethanolamine
Characteristic of phospholipid head group
Hydrophilic
Two fatty acids in phospholipid
1 saturated fatty acid
1 unsaturated fatty acid
Characteristic of phospholipid bilayer
Polar and nonpolar region
Phospholipid can be found in the lungs as what substance?
Surfactant
Detected in what bodily fluid during fetal lung maturity test?
Amniotic fluid
Considered as the building blocks of lipids
Fatty acids
Structure of fatty acids
Hydrocarbon chains with terminal COOH group
What can be usually found in triglycerides, phospholipids and cholesterol
Fatty acids
What form can fatty acids take in plasma
Free fatty acids
What protein does the majority of free fatty acids bind to
Albumin
3 Forms of fatty acids
Saturated fatty acid
Unsaturated fatty acid
Trans fatty acid
What fatty acid has no double bonds
Saturated fatty acids
Fatty acid with double bond/s (cis form)
Unsaturated fatty acids
Fatty acid with double bond/s (trans form)
Trans fatty acid
Function of lipoproteins
Transport lipids
What protein transports lipids
Lipoproteins
4 Normal Lipoproteins
Chylomicron
Very Low Density Lipoproteins
Low Density Lipoproteins
High Density Lipoproteins
Largest and lightest (lowest density)
Lipoprotein
Chylomicron
What lipoprotein transports exogenous triglycerides
Chylomicron
What triglycerides are derived from diet
Exogenous triglycerides
Remains in the origin during electrophoresis due to having no charge
Chylomicron
Causes non-fasting lipemia
Chylomicron
Pre-beta lipoprotein
Very Low Density Lipoprotein
Transports endogenous triglycerides
Very Low Density Lipoprotein
What triglyceride is produced by the body
Endogenous triglyceride
Known as the bad cholesterol
Low Density Lipoprotein
Beta lipoprotein
Low density Lipoprotein
Transports majority (75%) of the cholesterol from the liver throughout the body
Low density lipoprotein
What are the possible clinical complications of one who has high levels of LDL
Atherosclerosis
Coronary Heart Disease
Smallest and heaviest lipoprotein
High density lipoprotein
What lipoprotein has the highest lipid content
Chylomicron
Arrange from least to most the lipoproteins in regards to their protein content
Chylomicron-VLDL-LDL-HDL
What transport mechanism is HDL capable of
Reverse cholesterol transport (from cells to liver)
Arrange in increasing order the lipoproteins in regards to distance travelled during electrophoresis
Chylomicrons-VLDL-LDL-HDL
Good cholesterol
HDL