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CC1 MIDTERM - LIPIDS > LIPIDS and LIPOPROTEINS > Flashcards

LIPIDS and LIPOPROTEINS Flashcards

1
Q

basically fats

A

lipids

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2
Q

major class of dietary lipids

A

Triglycerides

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3
Q

lipids that are solid at RT

A

Fats

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4
Q

lipids that are liquid at RT

A

Oils

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5
Q

constituent of cell membranes

A

Phospholipids

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6
Q

forms of Phospholipids with percentage

A
  • 70% Lecithin/Phosphatidyl choline
  • 20% Sphingomyelin
  • 10% Cephalin
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7
Q

precursor of steroid hormones

A

Cholesterol

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8
Q

not used for energy

A

cholesterol

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9
Q

building blocks of lipids

A

fatty acids

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10
Q

bound to the proteins which allow fats to move through the water in and out of cells

A

Lipoproteins

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11
Q

most dense to least lipoprotein

A

HDL > LDL > VLDL

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12
Q

Heaviest to lightest based on molecular weight

A

Chylomicron > VLDL > LDL > HDL

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13
Q

Components of Chylomicron

A
  • 85-92% TAG
  • 6-12% Phospholipids
  • 1-3% Cholesterol
  • 1-2% Proteins
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13
Q

this is the responsible for POST-PRANDIAL TURBIDITY of sample

A

chylomicron

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14
Q

Types of Lipoproteins

A
  • Chylomicron
  • VLDL
  • IDL
  • LDL
  • HDL
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15
Q

responsible for FASTING HYPERLIPIDEMIC TURBIDITY of sample

A

VLDL

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16
Q

Second highest TAG content

A

VLDL

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17
Q

VDLD remnant

A

IDL

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18
Q
  • transports TAGS, fats and cholesterol
  • promote the growth of atheroma
A

IDL

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19
Q

products of VLDL and IDL metabolism

A

LDL

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20
Q

most cholesterol-rich

A

LDL

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21
Q

aka BAD CHOLESTEROL

A

LDL

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22
Q

phospholipid is the main lipidic content

A

HDL

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23
Q

aka GOOD CHOLESTEROL

A

HDL

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24
Q

synthesized in the liver and intestine

A

HDL

25
Q

smallest and densest lipoprotein

A

HDL

26
Q

proteins that bind lipids to form lipoprotein

A

Apolipoproteins

27
Q

serve as enzyme cofactors and receptor ligands

A

apolipoproteins

28
Q

LP Carried: Activator of LCAT for esterification

A

Apo A-1

29
Q

LP Carried: Chylomicrons

A

Apo B-48

30
Q

LP Carried: Lipemia clearing factor

A

Apo C-II

31
Q

LP Carried: Activates LPL, targets TAG and removes CM after meal

A

Apo C-II

32
Q

LP Carried: Increased in Alzheimer’s Dx

A

Apo E

33
Q

Lipid Storage Diseases: Accumulation of sphingomyelin in the
bone marrow, spleen and lymph
nodes

A

NIEMANN-PICK
DISEASE

34
Q

Lipid Storage Disease: orange or yellow discoloration of tonsils and pharynx

A

TANGIER’S
DISEASE

35
Q

Lipid Storage Disease:
- Deficiency of hexosaminidase A
- Accumulation of sphingolipids in the
brain

A

TAY-SACH’S
DISEASE

36
Q

Lipid Storage Disease: Chylomicron-retention disease

A

ANDERSON’S
DISEASE

37
Q

Lipid Storage Diseases: Plant sterols absorbed and accumulated in the blood and tissues

A

SITOSTEROLEMIA

38
Q

not affected by fasting

A

Cholesterol determination

39
Q

Specimen used

A

Serum or Plasma EDTA

40
Q

Cholesterol Measurement : Old reference method

A

Abell- Kendall Method

41
Q

3 step method of Abell-Kendall

A

Saponification - Extraction - Colorimetry

42
Q

end product and color of Abell-Kendall Method

A

Cholestadienyl monosulfuric acid , GREEN

43
Q

Cholesterol Measurement: Current reference method

A

Abell, Levey, Brody Method

44
Q

reagents used and end color

A

Libermann-Burchard rgt + KOH and alcoholic hexane , GREEN

45
Q

4 step method of Sperry Method

A

Saponification - Extraction - Colorimetry - Purification with digitonide

46
Q

end product and end color of Salkowski Method

A

Cholestadienyl disulfuric acid, RED

47
Q

Cholesterol Measurement: most commonly used

A

Enzymatic Method

48
Q

interferences of Enzymatic Method

A

ascorbate, hemoglobin, bilirubin

49
Q

Cholesterol Measurement: Definitive Method

A

Isotope Dilution/Mass spectrometry

50
Q

Triglycerid Measurement: Colorimetric Method

A

Van Handel & Zilversmit Method

51
Q

Reagent and End Color for Van Handel & Zilversmit Method

A

Chromotropic acid , BLUE

52
Q

Triglyceride Measurement: Colorimetric Method and Reference Method

A

Modified Van Handel & Zilversmit Method

53
Q

Reagent and End Color for Modified Van Handle & Zilversmit Method

A

Sulphuric Acid and Salicylic Acid, PINK

54
Q

Triglyceride Measurement: Fluorometric Method

A

Hantzsch Method

55
Q

Reagent and End Color for Hantzsch Method

A

Acetylacetone (diacetyl acetone) , YELLOW

56
Q

Lipoprotein Analysis : Reference Method and is measure in Svedverg units

A

Ultracentrifugation

57
Q

Reagent for Ultracentrifugation

A

Potassium bromide with 1.063 density

58
Q

Ultracentrifugation: Floating Layer

A

Chylomicron, VLDL

59
Q

Ultracentrifugation: Sinking Layer

A

LDL, HDL

60
Q

Preferred Gel for Electrophoresis

A

agarose gel

61
Q

Electrophoresis: from origin to the most anodal

A

Chylomicron, LDL, VLDL, HDL

CC1 MIDTERM - LIPIDS (1 decks)

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