Lipids Flashcards
phosphatidylcholine
glycerophospholipid
outer leaflet
phosphatidyl serine
glycerophospholipid
exposed to surface of apoptotic cells - move from inner to outer
cardiolipin
glycerophospholipid
abundant in INNER MITO MEMBR ONLY
Dipalmitoylphosphatidylcholinde (DPPC)
-glycerophospholipid
-part of surfactant, low level in neonates so incr respiratory distress
L/S > 2 –> fetal lung mature
L/S < 1.5 –> not mature, incr risk RDS
Plasmalogens and platelet activating factor (PAF)
- glycerophospholipid
- ether instead of ester linkage
glycerophospholipid xture
glycerol backbone with 3 branches: 1 sat FA, 1 unsat FA, and base with phosphate
sphingophosphylipid
is a type of phospholipid
-sphingomyelin
sphingomyelin
- sphingophospholipid
- outer leaflet
- lipid raft
- abundant in MYELIN SHEATH
- sphingosine backbone with 2 branches: FA and choline w phosphate
ceramine
sphingosine backbone with 1 FA
-used in sphingomyelin (sphingophospholipid) and all glycolipids
glycolipids
- outer leaflet - form glycolax
- lipid raft
- impt in myelin sheath
- cerebroside, sulfatide, globoside, ganglioside
- also glycosphingolipids/ sphingoglycolipids
oleic acid
MUFA
- olive oil
- 18C
Cholesterol
- lipid raft
- ampipathic
- derived lipid
Saturated FAs
- short chain, med and long chain
- no double bond
palmitic acid
long chain saturated FA
-16 C
steric acid
long chain saturated FA
- 18 C
- synth oleic acid
what are the omega 6 FAs
- linoleic (C18) *essential 2 double bond
- arachidonic acid (C20)- 4 double bond – synth eicosanoids (proinflammatory)
What are the omega-3 FAs
alpha linolenic acid (ALA) (C18) *essential, 3 double bond
- eicosapentanoic acid (EPA), (C20) 5 double bond (antiinflammatory, cardio protective)
- docasahexanoic acid (DHA) (C33) 6 double bond
Which FAs have increased fluidity
arachidonic acid and docosahexanoic acid (DHA)
bc incr double bond
cerebroside
glycosphingolipid
-ceramide + monosacch
sulfatide
glycosphingolipid
-ceramide + monosacch + sulfate
globoside
glycosphingolipid
-ceramide + oligosacch
ganglioside
glycosphingolipid
-ceramide + oligosacch + NANA (9C sugar)