Lipids Flashcards
Which particular fatty acids are critically important to proper development as well as inflammatory and other physiological processes?
Arachidonic acid, eicosapentaenoic acid (EPA), and docohexaenoic acid (DHA)
What are the basic contents of triglyceride structure?
A glycerol backbone and various fatty acids attached in ester linkage at the carbon-1 (sn-1), carbon-2 (sn-2), and carbon-3 (sn-3) positions
Why does a gram of fat stored in tissue have more recoverable energy than a gram of carbohydrate?
TGs have a lower intrinsic level of oxidation than carb, and the weight contribution of water common to carbs and proteins is missing from lipids
Which fatty acids necessary for life can humans not synthesize and why?
Linoleic acid and alpha-linolenic acid. The specific desaturase enzymes that can introduce a doube bond past position 9-10 within a given fatty acid are absent, which prevents the de novo synthesis of linoleic and alpha-linoleic acids.
Linoleic acid and alpha-linolenic acid serve as precursors for the synthesis of which other necessary long-chain unsaturated fatty acids?
Arachidonic acid (AA) and docohexaenoic acid (DHA)
What is the intestinal activity that is critical for metabolism of long-chain TGs?
The emulsification process and micelle formation that makes TGs and fatty acid esters available for hydrolysis by intestinal lipases and esterases
What types of fats can be directly absorbed in the villi of the intestinal mucosa?
Ingested glycerol and individual fatty acids. MCT (medium-chain triglycerides) lipid emulsions can be directly absorbed without requiring either bile salts for emulsification or energy for uptake
What are ILEs (lipid injectable emulsion), and what concentrations are available in commercial ILEs?
Oil-in-water emulsions consisting of 1 or more TG-containing oils, glycerin, and a phospholipid emulsifier, available in concentration of 10%, 20%, and 30% (w/v).
How can hypertriglyceridemia occur with the provision of lipids in PN?
It occurs when the body cannot clear TGs from plasma lipids via oxidation and/or storage in adipose tissue, and it may be caused when the supply of lipids into the bloodstream exceeds lipoprotein lipase activity or when lipoprotein activity is reduced
What is the most common pathway of oxidative degradation of fatty acids?
Beta-oxidation
What is the suggested % of total energy as linoleic acid and alpha-linolenic acid that should be provided to prevent essential fatty acid deficiency (EFAD)?
1-4% for linoleic acid
0.25-0.5% for alpha-linolenic acid
The two 100% soybean oil-based emulsions available for IV use in the US provide what percent of total energy from linoleic and alpha-linolenic acid?
55-60% of energy from linoleic acid and 3-4% total energy from alpha-linolenic acid
What is the most common lipid regimen in adult PN patients with 100% soybean oil-based ILEs that is prescribed to meet EFA requirements?
500 ml of a 20% ILE may be given weekly
ASPEN guideline when using soybean oil emulsion as the sole IV fat sourse?
The ILE should be held for the first week or given at a maximum of 100 g/week if there is concern or risk for EFAD
In adult patients requiring PN, ILEs should not exceed ___ g lipid per kg per day
2.5 g
It is recommended that the infusion rate for ILEs does not exceed ___ gm/kg/hour, for what reason?
Recommended to limit the infusion rate so it does not exceed 0.11 gm/kg/hour to prevent potential adverse reactions or toxicities associated with rapid infusion