Lipid transport and Dyslipidaemia Flashcards
What is the density of Chylomicrons?
Less than 0.95 kg/L
What is the diameter of Chylomicrons?
75-1200 microns
What is the major lipid(s) that make up Chylomicrons?
Triglycerides
Which apoproteins are contained within Chylomicrons?
Apoprotein B-48 is the main structural protein and one is contained within each chylomicron.
Other apoproteins that are present include:
Apoprotein A, C and E
What is the main function of Chylomicrons?
Chylomicrons are responsible for the transport of dietary cholesterol and triglycerides to peripheral tissue and the liver.
What is the density of VLDL lipoproteins?
0.930- 1.006 kg/L
What is the diameter of VLDL?
30-80 microns
What is the major lipid(s) that make up VLDL?
Triglycerides
Which apoproteins are contained within VLDL?
Apoprotein B100, Apoprotein C and E
What is the main function of VLDL?
Responsible for the transport of triglycerides and cholesterol (but mainly triglycerides due to its composition) into peripheral tissues. The Apo B100 expressed acts as a substrate for the LDL receptors expressed on these tissues allowing the uptake of TG and cholesterol into the tissues.
What is the density of IDL lipoproteins?
1.006- 1.019 kg/L
What is the diameter of IDL?
25-35 microns
What is the major lipid(s) that make up IDL?
Triglycerides
Cholesterol
Which apoproteins are contained within IDL?
Apoprotein B100 and Apoprotein E
What is the main function of IDL?
Responsible for the transport of triglycerides and cholesterol into peripheral tissues. The Apo B100 contained within the lipoprotein acts as a substrate for the LDL receptors expressed on these tissues allowing the uptake of TG and cholesterol into the tissues.
What is the density of LDL lipoproteins?
1.019- 1.063 kg/L
What is the diameter of LDL?
18-25 microns
What is the major lipid(s) that make up LDL?
Cholesterol
Which apoproteins are contained within LDL?
Apoprotein B100
What is the main function of LDL?
Responsible for the transport of triglycerides and cholesterol (but mainly cholesterol due to its composition) into peripheral tissues. The Apo B100 expressed acts as a substrate for the LDL receptors expressed on these tissues allowing the uptake of TG and cholesterol into the tissues.
What is the density of HDL lipoproteins?
1.063- 1.210 kg/L
What is the diameter of HDL?
5-12 microns
What is the major lipid(s) that make up HDL?
Protein (Apoprotein A1 contributes to 70%)
Which apoproteins are contained within HDL?
Apoprotein A1, Apoprotein A2, Apoprotein C and Apoprotein E
What is the main function of HDL?
HDL is a crucial lipoprotein involved in the reverse cholesterol transport. It is responsible for facilitating the removal of excess cholesterol within cells and peripheral tissue back to hepatocytes where it is either redistributed to elsewhere in the body or eliminated via the gall bladder.
