Lipid transport

Question 1

What is Type I familial dyslipidemia?

Answer 1

hyperchylomicronemia. (AR). MC due to lipoprotein lipase deficiency of ApoCII mutation. pancreatitis, hepatosplenomegaly, xanthomas (BUT NO INCREASED RISK OF CAD b/c LDL and HDL are normal)

Question 2

What is Type IIa familial dyslipidemia?

Answer 2

absent or defective LDL receptors. (AD) heterozygotes have cholesterol = 300, homozygotes have cholesterol around 700. accelerated atherosclerosis (MI before 20), Achilles tendon xanthomas, corneal arcus. high LDL in blood

Question 3

What is Type IV familial dyslipidemia?

Answer 3

hepatic overproduction of VLDL. (AD) can cause pancreatitis. high VLDL, TG in blood

Question 4

What does Apolipoprotein E do?

Answer 4

mediates remnant uptake (notably picked up by circulating chylomicrons from HDL and they use this to get to liver)

Question 5

What does Apolipoprotein A-I do?

Answer 5

activates LCAT (only on chylomicron, HDL)

Question 6

What does Apolipoprotein C-II do?

Answer 6

lipoprotein lipase cofactor (chylomicrons, VLDL, HDL)

Question 7

What does Apolipoprotein B-48 do?

Answer 7

mediates chylomicron secretion from small intestine

Question 8

What does Apolipoprotein B-100 do?

Answer 8

binds to LDL receptor