Lipid Metabolism 1

Question 1

What is the first step of Lipid absorption?

Answer 1

Bile salts emulsify dietary fats in the small intestine, forming mixed micelles

Question 2

What is the second step of lipid absorption?

Answer 2

Intestinal lipases degrade traicylglycerols

Question 3

What is the third step of lipid absorption?

Answer 3

Fatty acids and other breakdown products are taken up by the intestinal mucosa and converted into traicylglycerols.

Question 4

What is the fourth step of lipid absorption?

Answer 4

Triacylglycerols are incorporated, with cholesterol and apoproteins into chylomicrons.

Question 5

What is the fifth step of lipid absorption?

Answer 5

Chylomicrons move through the lymphatic system and bloodstream to tissues.

Question 6

What is the sixth step of lipid absorption?

Answer 6

Lipoprotein lipase, activated by apoC-11 in the capillary releases fatty acid and glycerol.

Question 7

What is the seventh step of lipid absorption?

Answer 7

Fatty acids enter cells.

Question 8

What is the eighth step of lipid absorption?

Answer 8

Fatty acids are oxidized as fuel or re-esterified for storage.

Question 9

What is the function of apoE?

Answer 9

It activates receptor-mediated endocytosis of lipoprotein made from chylomicron remnants

Question 10

What is the function of apo C-2?

Answer 10

apo C-2 activates hydrolysis of triacylglycerols by lipoprotein lipase on the surface of cells.

Question 11

What is the result of Apo C-2 deficiency?

Answer 11

Apo C-2 deficiency produces high levels of triacylglycerol in humans.

Question 12

What is the function of VLDL?

Answer 12

VLDL are vehicles for transport of fat from the liver to peripheraltissues. VLDL are formed in the liver with triglycerols, cholesterol and apoproteins. They acquire additional apoprotein (C-11) i

Question 13

Explain the hormonal regulation of fatty acid mobilization

Answer 13

When low levels of glucose in the blood trigger the release of glucagon