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Pharm > Lipid Lowering Agents > Flashcards

Lipid Lowering Agents Flashcards

1
Q

Most effective at lowering LDLs and TC

A

Statins

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2
Q

2 weeks to see a reduction in LDLs, 6-8wks for therapeutic level

A

Statins

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3
Q

Primarily used as adjuncts, or as second line

A

Bile sequestrants

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4
Q

Most effective in lowering triglycerides and increasing HDLs

A

Fibrates

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5
Q

Creates more LDL receptors in liver and more HDL to bring LDLs back for recycling

A

Statins

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6
Q

Prevents reabsorption by forming complex with cholesterol in bile acids to be excreted

A

Bile sequestrants

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7
Q

Activate lipoprotein lipase and increases secretion of cholesterol into bile

A

Fibrates

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8
Q

Beneficial actions of statins

A

Allow BVs to dilate, improves abnormal endothelial wall production, stabilizes atherosclerotic plaques, reduces formation of thrombin, reduces risk of thrombis, decreased inflammation at site, decreased risk of a fib, decreased calcification at site.

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9
Q

Used in primary and secondary prevention of CV events

A

Statins

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10
Q

Used in post MI therapy

A

Statins

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11
Q

Can decrease mortality in diabetes by controlling risk factors

A

Statins

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12
Q

Used in patients with partial biliary obstruction

A

Novo-choline, a bile sequestrant

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13
Q

Decreases elevated plasma triglycerides and raises HDLs

A

Fibrates

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14
Q

Can cause hepatotoxicity

A

Statins

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15
Q

Can cause myopathy that leads to myositis that leads to rhabdomyolosis

A

Statins

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16
Q

Can cause new onset diabetes

A

Statins

17
Q

Can cause memory loss

A

Statins

18
Q

Can cause cataracts

A

Statins

19
Q

Can decrease fat absorption therefore decreasing uptake of fat soluble vitamins

A

Bile sequestrants

20
Q

Can cause gallstones so best to avoid use in patients with a history

A

Fibrates

21
Q

Can cause liver injury so a baseline liver test before and during therapy is required

A

Fibrates

22
Q

Interacts with other lipid lowering agents, mainly Fibrates

A

Statins

23
Q

Forms insoluble complexes with other meds, so have to be careful with dosing schedules

A

Bile sequestrants

24
Q

Interacts with warfarin, increasing anticoagulant effects

A

Fibrates

25
Q

Interacts with statins, increasing risk of myopathy

A

Fibrates

26
Q

Contraindicated in pregnancy and while breastfeeding

A

Statins

27
Q

Contraindicated with liver disease and elevated liver enzymes

A

Statins

28
Q

Can have higher blood levels in Asian populations vs Caucasians

A

Statins

Pharm (6 decks)

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