Lipid droplets types, contents, and lipoproteins

Question 1

Chylomicron components and contents

Answer 1

ApoB-48
TAGs mainly

After circulating, obtains Apo C-II and Apo-E from HDLs

Question 2

Nascent HDL

Answer 2

ApoA-I, Apo E, and ApoC-II
Mostly phospholipids (Disc HDL)

Question 3

HDL3

Answer 3

ApoA-I, ApoE, ApoC-II

Has just started filling

Mostly Cholesterols

Smaller than HDL2s

Question 4

HDL2

Answer 4

Mostly proteins

Has transfered chlesterols to VLDLs and absorbed some TAGs and Phospholipids.

Question 5

SR-B1

Answer 5

Unloads Cholesterol esters from HDL2’s into hepatocytes, liver.

Question 6

ABCA1

Answer 6

Transfers cholesterol from peripheral cells into Nascent HDLs to generate HDL3s

Question 7

VLDLs

Answer 7

Nascent VLDLs:
ApoB-100

Obtain ApoE and ApoCII from HDLs

Question 8

LPL lipoprotein lipase

Answer 8

unloads

Question 9

ApeE function

Answer 9

binds liver receptors for endocytosis

Question 10

ApoC-II function

Answer 10

Needed for LPL function.

Question 11

LDLs

Answer 11

ApoB-100
Highest density of Cholesterol and CE’s
Have received Cholesterol from HDL’s

Taken up by LDL receptors

Question 12

LDL receptor ligands

Answer 12

The ApoB-100 and Apo-E proteins of LDLs.

Question 13

Regulated step of cholesterol synthesis

Answer 13

HMG-CoA reductase reaction

HMG-CoA + 2NADPH –> Mevalonate

Question 14

From what compound are all of the Carbons of Cholesterol derived

Answer 14

Acetyl-CoA

Acetyl-CoA –> Acetoacetyl CoA –> HMG-CoA –> Mevalonate