LIPID DISORDER Flashcards
LDL is a
Bad cholesterol
HDL is a..
Good cholesterol
Dietary lipids is composed of
TG
Cholesterol
Triglycerides is composed of
Glycerol
3Fatty acid
What are the lipoprotein
Apoprotein
Cholesterol
Triglyceride
What is the summary sequence of the lipoproteins cycle
Chlylomicrons
VLDL
IDL
LDL
HDL
What is the meaning of dyslipidemia or hyperlipidemia
Imbalance of lipids in the body
What is the limit for hypertroglyceride
150mg/dL
hypercholesterolemia is based on ..
LDL
*not based on TOTAL CHOLESTEROL LEVELS
If the HDL cholesterol > 60 mg/dL
It is a Negative risk factor
What happen to Excess LDL
Deposited into the intima of the arteries
Intima-innermost of the endothelial
What are the other modification to the excess LDL
Non-enzyme glycation
Oxidation
In non-enzyme glycation
What will happen to the GLYCATED LDL
Mahirap masira
Mahirap pumasok sa liver
In oxidation what will happen to the OXIDIZED LDL
Oxidized LDL + macrophage
👉🏻lipid-laded macrophage(tataba macro)
👉🏻apoptosis(mamatay)
What will happen to apotosis
Calcification(maninigas)
👉🏻atheroma (matigas na artery)
and accumulation
What is the central roles of the liver in lipid handling
👉🏻repacks TG to become VLDL
👉🏻synthesizes bile acids
What are the sources of cholesterol of bile acids synthesis
👉🏻primary: De Novo synthesis
👉🏻alternative: 👆🏻LDL receptor
👆🏻HDL
Whee is the site in De Novo synthesis
Liver
De Novo synthesis is peak at..
Night
What are the drugs should be given in lipid disordes
HMG-CoA reductase(statins)
Fibric acids
Niacin
Bile acid sequesterant
Sterol absorption inhibitor
What is the effect of statins
👆🏻utilization of secondary sources
👇🏻LDL
👆🏻HDL
👇🏻VLDL
What are the types of statins
Short acting
Long acting
In short acting statins
The t1/2 is..
1-3hrs
In long acting statins
The t1/2 is..
14hrs
