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Pharmacology Chapter 5 > LIPID DISORDER > Flashcards

LIPID DISORDER Flashcards

1
Q

LDL is a

A

Bad cholesterol

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2
Q

HDL is a..

A

Good cholesterol

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3
Q

Dietary lipids is composed of

A

TG

Cholesterol

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4
Q

Triglycerides is composed of

A

Glycerol

3Fatty acid

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5
Q

What are the lipoprotein

A

Apoprotein

Cholesterol

Triglyceride

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6
Q

What is the summary sequence of the lipoproteins cycle

A

Chlylomicrons

VLDL

IDL

LDL

HDL

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7
Q

What is the meaning of dyslipidemia or hyperlipidemia

A

Imbalance of lipids in the body

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8
Q

What is the limit for hypertroglyceride

A

150mg/dL

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9
Q

hypercholesterolemia is based on ..

A

LDL

*not based on TOTAL CHOLESTEROL LEVELS

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10
Q

If the HDL cholesterol > 60 mg/dL

A

It is a Negative risk factor

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11
Q

What happen to Excess LDL

A

Deposited into the intima of the arteries

Intima-innermost of the endothelial

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12
Q

What are the other modification to the excess LDL

A

Non-enzyme glycation

Oxidation

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13
Q

In non-enzyme glycation

What will happen to the GLYCATED LDL

A

Mahirap masira

Mahirap pumasok sa liver

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14
Q

In oxidation what will happen to the OXIDIZED LDL

A

Oxidized LDL + macrophage
👉🏻lipid-laded macrophage(tataba macro)
👉🏻apoptosis(mamatay)

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15
Q

What will happen to apotosis

A

Calcification(maninigas)
👉🏻atheroma (matigas na artery)

and accumulation

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16
Q

What is the central roles of the liver in lipid handling

A

👉🏻repacks TG to become VLDL

👉🏻synthesizes bile acids

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17
Q

What are the sources of cholesterol of bile acids synthesis

A

👉🏻primary: De Novo synthesis

👉🏻alternative: 👆🏻LDL receptor
👆🏻HDL

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18
Q

Whee is the site in De Novo synthesis

A

Liver

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19
Q

De Novo synthesis is peak at..

A

Night

20
Q

What are the drugs should be given in lipid disordes

A

HMG-CoA reductase(statins)

Fibric acids

Niacin

Bile acid sequesterant

Sterol absorption inhibitor

21
Q

What is the effect of statins

A

👆🏻utilization of secondary sources

👇🏻LDL
👆🏻HDL
👇🏻VLDL

22
Q

What are the types of statins

A

Short acting

Long acting

23
Q

In short acting statins

The t1/2 is..

A

1-3hrs

24
Q

In long acting statins

The t1/2 is..

A

14hrs

25
Q

What are the drugs in short acting

A

Simvastatin

Pravastatin

26
Q

The short acting simvastatin should be taken

A

At Night

27
Q

What are the drugs in long acting statins

A

Atorvastatin

Rosuvastatin

28
Q

Long acting statins should be taken every

A

Any time of the day

29
Q

What are the use in statins

A

1st line in hypercholesterolemia

For stabilization of atheromatus plaque

30
Q

SE of statins

A

Hepatotoxicity
Myalgia
Rhabdomyolysis
Teratogenicity

31
Q

What is the MOA of fibric acid der

A

Stimulate lipoprotein lipase

32
Q

Fibric acids can..

A

👆🏻VLDL 👇🏻TG

👆🏻HDL 👇🏻LDL

33
Q

What are the drugs in fibric acid derv

A

Fenofibrate

Clofibrate

Gemfibrozil

34
Q

What are the uses of fibric acid

A

1st line mgt of hypertriglyceridemia

Mgt metabolic syndrome

35
Q

SE of fibric acid

A

Rhabdomyolysis

👆🏻risk stone formation

Clofibrate-hepatobiliary

36
Q

What is the MOA of niacin

A

Inhibit synthesis and release of VLDL stimulate LPL

37
Q

What is the use in niacin

A

Alt. In the mgt if hypertriglyceridemia

38
Q

SE of niacin

A

Hepatotoxicity

Flushing

39
Q

What is the remedy in flushing in SE of niacin

A

Nsaids

40
Q

What is the MOA of bile acid sequestrants

A

Inhibit biliary recycling

👇🏻LDL
👆🏻HDL

41
Q

What are the drugs in bile acid

A

Cholestyramine

Colestipol

Colesevelam

42
Q

What is the us of bile acid

A

Add ons to statins

Mgt of some drug toxicity
👉🏻warfarin
👉🏻digoxin

43
Q

What is the SE of bile acid

A

👆🏻risk of bile-stone formation

Malabsorption if some vitamin

44
Q

What is the drug in sterol absorption

A

Ezetimibe

45
Q

What is the MOA of sterol absorption

A

Inhibit NPC1L1 transporter

46
Q

What is the use of sterol absorption

A

Add on to statins

Pharmacology Chapter 5 (1 decks)

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